MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00062179" target="_blank" >RIV/00216224:14740/12:00062179 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas

Popis výsledku v původním jazyce

High-grade gliomas are highly malignant primary brain tumors of supportive glial cells origin. Despite optimal course of treatment, including maximal surgical resection followed by chemo- and/orradiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo-radioresistance that is manifested by early progression after or even during oncology treatment. Accurate prediction of therapy response and adjuvant therapeutic approach enabling an overcoming of resistance consist the main aims of glioma translationalresearch. The important role in therapeutic resistance play cancer stem cells (CSCs) and thus, signaling pathways related to maintaining stem-like phenotype. Glioma stem cells (GSCs) are associated with time to progression and overall survival of glioma patients. In recent years, it was shown that biological features of GSCs could be effectively regulated by microRNAs (miRNAs), short endogenou RNA molecules that post-transcriptionally regulate gene expr

Název v anglickém jazyce

MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas

Popis výsledku anglicky

High-grade gliomas are highly malignant primary brain tumors of supportive glial cells origin. Despite optimal course of treatment, including maximal surgical resection followed by chemo- and/orradiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo-radioresistance that is manifested by early progression after or even during oncology treatment. Accurate prediction of therapy response and adjuvant therapeutic approach enabling an overcoming of resistance consist the main aims of glioma translationalresearch. The important role in therapeutic resistance play cancer stem cells (CSCs) and thus, signaling pathways related to maintaining stem-like phenotype. Glioma stem cells (GSCs) are associated with time to progression and overall survival of glioma patients. In recent years, it was shown that biological features of GSCs could be effectively regulated by microRNAs (miRNAs), short endogenou RNA molecules that post-transcriptionally regulate gene expr

Druh

O - Ostatní výsledky

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů