The effect of sertindole on behavioural sensitisation to methamphetamine in mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00063522" target="_blank" >RIV/00216224:14740/12:00063522 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/12:43870989

Výsledek na webu

<a href="http://vri.cz/docs/vetmed/57-11-603.pdf" target="_blank" >http://vri.cz/docs/vetmed/57-11-603.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The effect of sertindole on behavioural sensitisation to methamphetamine in mice

Popis výsledku v původním jazyce

Similarly to various other addictive substances, Methamphetamine (Met) produces, following repeated application, a strong increase in behavioural responses (particularly locomotor behaviour), a phenomenon termed behavioural sensitisation. In our previousstudies we tested the effects of various psychotropic drugs on behavioural sensitisation to Met, particularly the effects of cannabinoid receptor ligands with different intrinsic activities and felbamate and memantine, antagonists of N-methyl-d-aspartate (NMDA) receptors. In the present study we investigated the influence of the antipsychotic drug sertindole (Srt) on sensitisation to the effects of Met on mouse locomotor behaviour in the Open field test. Male mice were randomly divided into 4 groups and were administered drugs seven times (from the 7th to 13th day of the experiment) as follows: (a) n1, 2: Met at doses of 2.5 mg/kg/day; (b) n3: Met + Srt at doses of 2.5 mg/kg/day + 10.0 mg/kg/day; (c) n4: Srt at a dose of 10.0 mg/kg/day

Název v anglickém jazyce

The effect of sertindole on behavioural sensitisation to methamphetamine in mice

Popis výsledku anglicky

Similarly to various other addictive substances, Methamphetamine (Met) produces, following repeated application, a strong increase in behavioural responses (particularly locomotor behaviour), a phenomenon termed behavioural sensitisation. In our previousstudies we tested the effects of various psychotropic drugs on behavioural sensitisation to Met, particularly the effects of cannabinoid receptor ligands with different intrinsic activities and felbamate and memantine, antagonists of N-methyl-d-aspartate (NMDA) receptors. In the present study we investigated the influence of the antipsychotic drug sertindole (Srt) on sensitisation to the effects of Met on mouse locomotor behaviour in the Open field test. Male mice were randomly divided into 4 groups and were administered drugs seven times (from the 7th to 13th day of the experiment) as follows: (a) n1, 2: Met at doses of 2.5 mg/kg/day; (b) n3: Met + Srt at doses of 2.5 mg/kg/day + 10.0 mg/kg/day; (c) n4: Srt at a dose of 10.0 mg/kg/day

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinarni Medicina

ISSN

0375-8427

e-ISSN

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Svazek periodika

57

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

603-609

Kód UT WoS článku

000313211200006

EID výsledku v databázi Scopus

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