MicroRNAs in solid cancer: from biomarkers to therapeutic targets

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00065597" target="_blank" >RIV/00216224:14740/13:00065597 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

MicroRNAs in solid cancer: from biomarkers to therapeutic targets

Popis výsledku v původním jazyce

MicroRNAs (miRNAs) are small non-coding RNAs 18?25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and development. Changes in the expression profiles of miRNAs have been observed in a variety of human solid tumors. Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend concept of molecular pathogenesis of cancer and have shown great potential for miRNAs as a novel class of therapeutic targets. Several investigations have also described the ability of miRNA expression profiles to predict prognosis and response to selected treatments in cancer patients, and support diagnosis of origin among cancer of unknown primary site. MiRNAs? occurrence has been repeatedly observed also in blood serum and plasma, and miRNAs as novel minimally invasive biomarkers have indicated reasonable sensitivity for cancer detection.

Název v anglickém jazyce

MicroRNAs in solid cancer: from biomarkers to therapeutic targets

Popis výsledku anglicky

MicroRNAs (miRNAs) are small non-coding RNAs 18?25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and development. Changes in the expression profiles of miRNAs have been observed in a variety of human solid tumors. Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend concept of molecular pathogenesis of cancer and have shown great potential for miRNAs as a novel class of therapeutic targets. Several investigations have also described the ability of miRNA expression profiles to predict prognosis and response to selected treatments in cancer patients, and support diagnosis of origin among cancer of unknown primary site. MiRNAs? occurrence has been repeatedly observed also in blood serum and plasma, and miRNAs as novel minimally invasive biomarkers have indicated reasonable sensitivity for cancer detection.

Druh

O - Ostatní výsledky

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů