Protein engineering of beta-D-mannosidase

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00066122" target="_blank" >RIV/00216224:14740/13:00066122 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Protein engineering of beta-D-mannosidase

Popis výsledku v původním jazyce

N-Acetyl-D-mannosamine (ManNAc) is often used as a precursor in the chemical or enzymatic synthesis of the neuraminic acids found in glycolipids and glycoproteins. ManNAc is also a synthetic intermediate for a number of carbohydrate-derived families of biologically active compounds and pharmaceutical candidates. For this reason ManNAc is of keen interest to scientists around the world. The main goal of this work, because no N-Acetyl-mannosaminidase has been identified in the nature, is to produce N-acetyl-mannosaminidase via mutagenesis of beta-D-mannosidase and to apply this new enzyme in possible enzymatic synthesis of structures containing ManNAc.

Název v anglickém jazyce

Protein engineering of beta-D-mannosidase

Popis výsledku anglicky

N-Acetyl-D-mannosamine (ManNAc) is often used as a precursor in the chemical or enzymatic synthesis of the neuraminic acids found in glycolipids and glycoproteins. ManNAc is also a synthetic intermediate for a number of carbohydrate-derived families of biologically active compounds and pharmaceutical candidates. For this reason ManNAc is of keen interest to scientists around the world. The main goal of this work, because no N-Acetyl-mannosaminidase has been identified in the nature, is to produce N-acetyl-mannosaminidase via mutagenesis of beta-D-mannosidase and to apply this new enzyme in possible enzymatic synthesis of structures containing ManNAc.

Druh

O - Ostatní výsledky

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP207%2F10%2F0321" target="_blank" >GAP207/10/0321: Enzymy metabolismu mannosidů v přípravě N-acetyl-mannosaminových struktur</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů