New family of bacterial lectins with seven bladed beta propeller fold
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00073681" target="_blank" >RIV/00216224:14740/14:00073681 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
New family of bacterial lectins with seven bladed beta propeller fold
Popis výsledku v původním jazyce
The crystal structures of BP39L and CV39L were determined based on a new class of lanthanide complexes for heavy atom derivatization (SAD experiment). The BP39L lectin crystallized in I222 space group and CV39L in P212121. The structures of both lectinsrevealed seven bladed beta propeller fold with possibly seven binding sites per monomer. The BP39L lectin was observed as a monomer and CV39L as a dimer in solution, which was confirmed also in the crystal structure. The knowledge about the structure together with sequence and structure predictions indicates that the proteins belong to an undescribed new family of lectins. The functional studies indicate the specificity of lectin BP39L towards mannose and CV39L towards fucose and galactose.
Název v anglickém jazyce
New family of bacterial lectins with seven bladed beta propeller fold
Popis výsledku anglicky
The crystal structures of BP39L and CV39L were determined based on a new class of lanthanide complexes for heavy atom derivatization (SAD experiment). The BP39L lectin crystallized in I222 space group and CV39L in P212121. The structures of both lectinsrevealed seven bladed beta propeller fold with possibly seven binding sites per monomer. The BP39L lectin was observed as a monomer and CV39L as a dimer in solution, which was confirmed also in the crystal structure. The knowledge about the structure together with sequence and structure predictions indicates that the proteins belong to an undescribed new family of lectins. The functional studies indicate the specificity of lectin BP39L towards mannose and CV39L towards fucose and galactose.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA13-25401S" target="_blank" >GA13-25401S: Studium proteinů z patogenů zapojených do rozpoznávání hostitelského organismu</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů