A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance.

Kód výsledku v IS VaVaI

RIV/00216224:14740/15:00085160 - isvavai.cz

Výsledek na webu

http://www.nature.com/doifinder/10.1038/nature16141

DOI - Digital Object Identifier

10.1038/nature16141

Jazyk výsledku

angličtina

Název v původním jazyce

A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance.

Popis výsledku v původním jazyce

T-cell receptor (TCR) signalling has a key role in determining T-cell fate. Precursor cells expressing TCRs within a certain low-affinity range for complexes of self-peptide and major histocompatibility complex (MHC) undergo positive selection and differentiate into naive T cells expressing a highly diverse self-MHC-restricted TCR repertoire. In contrast, precursors displaying TCRs with a high affinity for 'self' are either eliminated through TCR-agonist-induced apoptosis (negative selection) or restrained by regulatory T (Treg) cells, whose differentiation and function are controlled by the X-chromosome-encoded transcription factor Foxp3 (reviewed in ref. 2). Foxp3 is expressed in a fraction of self-reactive T cells that escape negative selection in response to agonist-driven TCR signals combined with interleukin 2 (IL-2) receptor signalling.

Název v anglickém jazyce

A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance.

Popis výsledku anglicky

T-cell receptor (TCR) signalling has a key role in determining T-cell fate. Precursor cells expressing TCRs within a certain low-affinity range for complexes of self-peptide and major histocompatibility complex (MHC) undergo positive selection and differentiate into naive T cells expressing a highly diverse self-MHC-restricted TCR repertoire. In contrast, precursors displaying TCRs with a high affinity for 'self' are either eliminated through TCR-agonist-induced apoptosis (negative selection) or restrained by regulatory T (Treg) cells, whose differentiation and function are controlled by the X-chromosome-encoded transcription factor Foxp3 (reviewed in ref. 2). Foxp3 is expressed in a fraction of self-reactive T cells that escape negative selection in response to agonist-driven TCR signals combined with interleukin 2 (IL-2) receptor signalling.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature

ISSN

0028-0836

e-ISSN

—

Svazek periodika

528

Číslo periodika v rámci svazku

7580

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

16

Strana od-do

"132"-"+"

Kód UT WoS článku

000365606000063

EID výsledku v databázi Scopus

—