Test-Retest Reproducibility of Neurochemical Profiles with Short-Echo, Single-Voxel MR Spectroscopy at 3T and 7T

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00092578" target="_blank" >RIV/00216224:14740/16:00092578 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/mrm.26022/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/mrm.26022/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mrm.26022" target="_blank" >10.1002/mrm.26022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Test-Retest Reproducibility of Neurochemical Profiles with Short-Echo, Single-Voxel MR Spectroscopy at 3T and 7T

Popis výsledku v původním jazyce

Purpose: To determine the test-retest reproducibility of neurochemical concentrations obtained with a highly optimized, short-echo, single-voxel proton MR spectroscopy (MRS) pulse sequence at 3T and 7T using state-of-the-art hardware. Methods: A semi-LASER sequence (echo time = 26-28 ms) was used to acquire spectra from the posterior cingulate and cerebellum at 3T and 7T from six healthy volunteers who were scanned four times weekly on both scanners. Spectra were quantified with LCModel. Results: More neurochemicals were quantified with mean Cramer-Rao lower bounds (CRLBs) &lt;= 20% at 7T than at 3T despite comparable frequency-domain signal-to-noise ratio. Whereas CRLBs were lower at 7T (P&lt;0.05), between-session coefficients of variance (CVs) were comparable at the two fields with 64 transients. Five metabolites were quantified with between-session CVs &lt;= 5% at both fields.

Název v anglickém jazyce

Test-Retest Reproducibility of Neurochemical Profiles with Short-Echo, Single-Voxel MR Spectroscopy at 3T and 7T

Popis výsledku anglicky

Purpose: To determine the test-retest reproducibility of neurochemical concentrations obtained with a highly optimized, short-echo, single-voxel proton MR spectroscopy (MRS) pulse sequence at 3T and 7T using state-of-the-art hardware. Methods: A semi-LASER sequence (echo time = 26-28 ms) was used to acquire spectra from the posterior cingulate and cerebellum at 3T and 7T from six healthy volunteers who were scanned four times weekly on both scanners. Spectra were quantified with LCModel. Results: More neurochemicals were quantified with mean Cramer-Rao lower bounds (CRLBs) &lt;= 20% at 7T than at 3T despite comparable frequency-domain signal-to-noise ratio. Whereas CRLBs were lower at 7T (P&lt;0.05), between-session coefficients of variance (CVs) were comparable at the two fields with 64 transients. Five metabolites were quantified with between-session CVs &lt;= 5% at both fields.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MAGNETIC RESONANCE IN MEDICINE

ISSN

0740-3194

e-ISSN

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Svazek periodika

76

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

1083-1091

Kód UT WoS článku

000388618400006

EID výsledku v databázi Scopus

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