Formulation Development, Physicochemical Characterization and In Vitro-In Vivo Drug Release of Vaginal Films

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00093893" target="_blank" >RIV/00216224:14740/16:00093893 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.eurekaselect.com/136942/article" target="_blank" >http://www.eurekaselect.com/136942/article</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1570162X14666151113123040" target="_blank" >10.2174/1570162X14666151113123040</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Formulation Development, Physicochemical Characterization and In Vitro-In Vivo Drug Release of Vaginal Films

Popis výsledku v původním jazyce

Purpose: The purpose of this study was formulation and optimization of vaginal film formulation containing abacavir (ABC), a potent nucleoside reverse transcriptase inhibitor. Methods: Vaginal films were prepared by solvent evaporation method using hydroxypropyl methylcellulose (HPMC) blended with polyvinyl pyrrolidone (PVP). Various physicochemical parameters of the prepared films such as drug content, thickness, tensile strength, percentage elongation at break, drug polymer interaction, swelling capacity, folding endurance, bio-adhesion, pH, and moisture content were evaluated with morphological studies. In vitro release study and in vivo release study were also performed. Results: Films exhibited favorable physicochemical properties. The in vitro study showed that HPMC-PVP combination can control the release of abacavir through vaginal films with higher amount of PVP in the formulation resulting in an enhanced drug release rate.

Název v anglickém jazyce

Formulation Development, Physicochemical Characterization and In Vitro-In Vivo Drug Release of Vaginal Films

Popis výsledku anglicky

Purpose: The purpose of this study was formulation and optimization of vaginal film formulation containing abacavir (ABC), a potent nucleoside reverse transcriptase inhibitor. Methods: Vaginal films were prepared by solvent evaporation method using hydroxypropyl methylcellulose (HPMC) blended with polyvinyl pyrrolidone (PVP). Various physicochemical parameters of the prepared films such as drug content, thickness, tensile strength, percentage elongation at break, drug polymer interaction, swelling capacity, folding endurance, bio-adhesion, pH, and moisture content were evaluated with morphological studies. In vitro release study and in vivo release study were also performed. Results: Films exhibited favorable physicochemical properties. The in vitro study showed that HPMC-PVP combination can control the release of abacavir through vaginal films with higher amount of PVP in the formulation resulting in an enhanced drug release rate.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CURRENT HIV RESEARCH

ISSN

1570-162X

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

12

Strana od-do

295-306

Kód UT WoS článku

000378058100001

EID výsledku v databázi Scopus

—