Sleep Deprivation and Structural Fluctuations in White Matter

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00094116" target="_blank" >RIV/00216224:14740/16:00094116 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Sleep Deprivation and Structural Fluctuations in White Matter

Popis výsledku v původním jazyce

Day-to-day stability of neuronal communication is essential for undistorted reconstructions of our perceptions, thoughts and emotions. To a great extent, such stability relies on the regulated delivery of molecules and organelles from neuronal cell bodies to discrete axonal compartments via axonal transport (AT). Sleep deprivation is one of the potential sources of altered AT, which is likely to have an impact on structural properties of white matter assessed in vivo with magnetic resonance imaging (MRI). The current study tested the hypothesis that short-term sleep deprivation, namely a restriction of sleep to 4 hours per nigth for 8 nights, will induce structural fluctuations in white matter, as identified by serial MRI. Multi-modal images of brain structure were acquired every two days (for 10 days) in two groups of young men: (1) Sleep-deprived group (n=12); and (2) Control (no sleep deprivation) group (n=12).

Název v anglickém jazyce

Sleep Deprivation and Structural Fluctuations in White Matter

Popis výsledku anglicky

Day-to-day stability of neuronal communication is essential for undistorted reconstructions of our perceptions, thoughts and emotions. To a great extent, such stability relies on the regulated delivery of molecules and organelles from neuronal cell bodies to discrete axonal compartments via axonal transport (AT). Sleep deprivation is one of the potential sources of altered AT, which is likely to have an impact on structural properties of white matter assessed in vivo with magnetic resonance imaging (MRI). The current study tested the hypothesis that short-term sleep deprivation, namely a restriction of sleep to 4 hours per nigth for 8 nights, will induce structural fluctuations in white matter, as identified by serial MRI. Multi-modal images of brain structure were acquired every two days (for 10 days) in two groups of young men: (1) Sleep-deprived group (n=12); and (2) Control (no sleep deprivation) group (n=12).

Druh

V_souhrn - Souhrnná výzkumná zpráva

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.

Počet stran výsledku

3

Místo vydání

Brno

Název nakladatele resp. objednatele

Child Mind Institute

Verze

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