Electrospun Biodegradable PCL, PEG and PCL/PEG Polyurethane Nanofibers Coated by Amine-rich Plasma Polymers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F17%3A00096398" target="_blank" >RIV/00216224:14740/17:00096398 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26620/16:PU123695

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Electrospun Biodegradable PCL, PEG and PCL/PEG Polyurethane Nanofibers Coated by Amine-rich Plasma Polymers

Popis výsledku v původním jazyce

The electrospinning process was employed for preparation of nanofiber substrates made of polycaprolactone (PCL), polyethylene glycol (PEG) and polyurethane (PUR). The used polymer solution and electrospinning process influenced the structure and biodegradability of the resulting nanofibers. Materials processed from PCL and PEG were imaged as well-structured nanofiber meshes, however, processing of PUR resulted as an electrosprayed film rather than nanofibers structure most likely due to the insufficient molecular weight of PUR.In order to improve the biocompatibility of the nanofibers a thin amine layer by means of the cyclopropylamineplasma polymerization in radio frequency capacitively coupled discharge was deposited on prepared nanofibrous meshes. The presence of the amine groups is supposed to enhance the adhesion and proliferation of the cells. Moreover, the possibility for further functionalizing of such nanofibers was tested on a model PUR foil made of PCL and PEG. The PUR surface was activated with amine layer via similar procedure as the nanofibers and further the grafting of chitosan was employed through carbodiimide-mediated coupling. Infrared spectroscopy confirmed successful grafting of chitosan onto the PUR surface. Overcoming the drawback of PUR nanofibers processing, e.g. by synthesizing PUR with higher molecular weight, can open possible use of the material in wound healing applications exploiting antibacterial properties of chitosan.

Název v anglickém jazyce

Electrospun Biodegradable PCL, PEG and PCL/PEG Polyurethane Nanofibers Coated by Amine-rich Plasma Polymers

Popis výsledku anglicky

The electrospinning process was employed for preparation of nanofiber substrates made of polycaprolactone (PCL), polyethylene glycol (PEG) and polyurethane (PUR). The used polymer solution and electrospinning process influenced the structure and biodegradability of the resulting nanofibers. Materials processed from PCL and PEG were imaged as well-structured nanofiber meshes, however, processing of PUR resulted as an electrosprayed film rather than nanofibers structure most likely due to the insufficient molecular weight of PUR.In order to improve the biocompatibility of the nanofibers a thin amine layer by means of the cyclopropylamineplasma polymerization in radio frequency capacitively coupled discharge was deposited on prepared nanofibrous meshes. The presence of the amine groups is supposed to enhance the adhesion and proliferation of the cells. Moreover, the possibility for further functionalizing of such nanofibers was tested on a model PUR foil made of PCL and PEG. The PUR surface was activated with amine layer via similar procedure as the nanofibers and further the grafting of chitosan was employed through carbodiimide-mediated coupling. Infrared spectroscopy confirmed successful grafting of chitosan onto the PUR surface. Overcoming the drawback of PUR nanofibers processing, e.g. by synthesizing PUR with higher molecular weight, can open possible use of the material in wound healing applications exploiting antibacterial properties of chitosan.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Nanocon 2016 - Proceedings

ISBN

9788087294710

ISSN

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e-ISSN

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Počet stran výsledku

7

Strana od-do

490-496

Název nakladatele

Tanger Ltd.

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

19. 10. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000410656100086