MicroRNAs as a tool to aid stratification of colorectal cancer patients and to guide therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F17%3A00100447" target="_blank" >RIV/00216224:14740/17:00100447 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.futuremedicine.com/doi/10.2217/pgs-2017-0004" target="_blank" >https://www.futuremedicine.com/doi/10.2217/pgs-2017-0004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2217/pgs-2017-0004" target="_blank" >10.2217/pgs-2017-0004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MicroRNAs as a tool to aid stratification of colorectal cancer patients and to guide therapy

Popis výsledku v původním jazyce

Colorectal cancer is a common type of malignant disease with high rates of morbidity and mortality. Although treatment options have been expanded over the last years, the mainstay of curative treatment remains surgical removal of the tumor-bearing organ. Systemic treatment options include classic cytotoxic drugs as well as some biological agents. Noncoding RNAs are an evolving field in cancer diagnosis, prognosis and possible treatment. Noncoding miRNAs are small molecules with huge impact on gene expression. They have been a substantial part of cancer research for more than a decade. In this review article, the current knowledge of miRNAs and colorectal cancer diagnosis, prognosis and novel or evolving therapeutic concepts are discussed. Examples of how miRNAs might change the management of the disease will be described.

Název v anglickém jazyce

MicroRNAs as a tool to aid stratification of colorectal cancer patients and to guide therapy

Popis výsledku anglicky

Colorectal cancer is a common type of malignant disease with high rates of morbidity and mortality. Although treatment options have been expanded over the last years, the mainstay of curative treatment remains surgical removal of the tumor-bearing organ. Systemic treatment options include classic cytotoxic drugs as well as some biological agents. Noncoding RNAs are an evolving field in cancer diagnosis, prognosis and possible treatment. Noncoding miRNAs are small molecules with huge impact on gene expression. They have been a substantial part of cancer research for more than a decade. In this review article, the current knowledge of miRNAs and colorectal cancer diagnosis, prognosis and novel or evolving therapeutic concepts are discussed. Examples of how miRNAs might change the management of the disease will be described.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PHARMACOGENOMICS

ISSN

1462-2416

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

1027-1038

Kód UT WoS článku

000405697300010

EID výsledku v databázi Scopus

2-s2.0-85024490495