Preparation of potential platinum-based metallodrugs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00101566" target="_blank" >RIV/00216224:14740/18:00101566 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Preparation of potential platinum-based metallodrugs

Popis výsledku v původním jazyce

Platinum anticancer agents represent one of the great success stories in the field of medicinal inorganic chemistry. However, current chemotherapeutics are rather non-selective and their undesired reactivity during the delivery to cancer tissue is responsible for severe side effects [1]. These anticancer agents would greatly benefit from protection during the transport in blood stream, and targeted delivery towards specific cancer tissues [2]. Therefore, preparation of Pt compounds decorated with anchor-type ligands suitable for encapsulation in macrocyclic cavitands was our goal in this study. Synthesis of novel platinum coordination compounds containing bulky adamantane ligands, their characterization by heteronuclear NMR spectroscopy and binding of these complexes into macrocyclic carriers were discussed. [1] Dilruba, S., Kalayda, G. V., Platinum-based drugs: past, present and future. In Cancer Chemother. Pharmacol., 2016, vol. 77, p. 1103-1124. [2] Wang, X., Guo, Z., Targeting and delivery of platinum-based anticancer drugs. In Chem. Soc. Rev., 2013, vol. 42, p. 202-224.

Název v anglickém jazyce

Preparation of potential platinum-based metallodrugs

Popis výsledku anglicky

Platinum anticancer agents represent one of the great success stories in the field of medicinal inorganic chemistry. However, current chemotherapeutics are rather non-selective and their undesired reactivity during the delivery to cancer tissue is responsible for severe side effects [1]. These anticancer agents would greatly benefit from protection during the transport in blood stream, and targeted delivery towards specific cancer tissues [2]. Therefore, preparation of Pt compounds decorated with anchor-type ligands suitable for encapsulation in macrocyclic cavitands was our goal in this study. Synthesis of novel platinum coordination compounds containing bulky adamantane ligands, their characterization by heteronuclear NMR spectroscopy and binding of these complexes into macrocyclic carriers were discussed. [1] Dilruba, S., Kalayda, G. V., Platinum-based drugs: past, present and future. In Cancer Chemother. Pharmacol., 2016, vol. 77, p. 1103-1124. [2] Wang, X., Guo, Z., Targeting and delivery of platinum-based anticancer drugs. In Chem. Soc. Rev., 2013, vol. 42, p. 202-224.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/GA16-05961S" target="_blank" >GA16-05961S: Pokročilé nosiče platinových léčiv</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů