An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00103871" target="_blank" >RIV/00216224:14740/18:00103871 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.parkreldis.2017.12.030" target="_blank" >http://dx.doi.org/10.1016/j.parkreldis.2017.12.030</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.parkreldis.2017.12.030" target="_blank" >10.1016/j.parkreldis.2017.12.030</a>

Jazyk výsledku

angličtina

Název v původním jazyce

An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group

Popis výsledku v původním jazyce

This expert working group report proposes an, updated approach to subtype definition of vascular parkinsonism (VaP) based on a review of the existing literature. The persistent lack of consensus on clear terminology and inconsistent conceptual definition of VaP formed the impetus for the current expert recommendation report. The updated diagnostic approach intends to provide a comprehensive tool for clinical practice. The preamble for this initiative is that VaP can be diagnosed in individual patients with possible prognostic and therapeutic consequences and therefore should be recognized as a clinical entity. The diagnosis of VaP is based on the presence of clinical parkinsonism, with variable motor and non motor signs that are corroborated by clinical, anatomic or imaging findings of cerebrovascular disease. Three VaP subtypes are presented: (1) The acute or subacute post-stroke VaP subtype presents with acute or subacute onset of parkinsonism, which is typically asymmetric and responds to dopaminergic drugs; (2) The more frequent insidious onset VaP subtype presents with progressive parkinsonism with prominent postural instability, gait impairment, corticospinal, cerebellar, pseudobulbar, cognitive and urinary symptoms and poor responsiveness to dopaminergic drugs. A higher-level gait disorder occurs frequently as a dominant manifestation in the clinical spectrum of insidious onset VaP, and (3) With the emergence of molecular imaging biomarkers in clinical practice, our diagnostic approach also allows the recognition of mixed or overlapping syndromes of VaP with Parkinson's disease or other neurodegenfor erative parkinsonisms. Directions for future research are also discussed. (C) 2018 Elsevier Ltd. All rights reserved.

Název v anglickém jazyce

An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group

Popis výsledku anglicky

This expert working group report proposes an, updated approach to subtype definition of vascular parkinsonism (VaP) based on a review of the existing literature. The persistent lack of consensus on clear terminology and inconsistent conceptual definition of VaP formed the impetus for the current expert recommendation report. The updated diagnostic approach intends to provide a comprehensive tool for clinical practice. The preamble for this initiative is that VaP can be diagnosed in individual patients with possible prognostic and therapeutic consequences and therefore should be recognized as a clinical entity. The diagnosis of VaP is based on the presence of clinical parkinsonism, with variable motor and non motor signs that are corroborated by clinical, anatomic or imaging findings of cerebrovascular disease. Three VaP subtypes are presented: (1) The acute or subacute post-stroke VaP subtype presents with acute or subacute onset of parkinsonism, which is typically asymmetric and responds to dopaminergic drugs; (2) The more frequent insidious onset VaP subtype presents with progressive parkinsonism with prominent postural instability, gait impairment, corticospinal, cerebellar, pseudobulbar, cognitive and urinary symptoms and poor responsiveness to dopaminergic drugs. A higher-level gait disorder occurs frequently as a dominant manifestation in the clinical spectrum of insidious onset VaP, and (3) With the emergence of molecular imaging biomarkers in clinical practice, our diagnostic approach also allows the recognition of mixed or overlapping syndromes of VaP with Parkinson's disease or other neurodegenfor erative parkinsonisms. Directions for future research are also discussed. (C) 2018 Elsevier Ltd. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PARKINSONISM &amp; RELATED DISORDERS

ISSN

1353-8020

e-ISSN

—

Svazek periodika

49

Číslo periodika v rámci svazku

APR

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

9-16

Kód UT WoS článku

000429395400003

EID výsledku v databázi Scopus

2-s2.0-85048926311