The human V delta 2(+) T-cell compartment comprises distinct innate-like V gamma 9(+) and adaptive V gamma 9(-) subsets

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00106544" target="_blank" >RIV/00216224:14740/18:00106544 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1038/s41467-018-04076-0" target="_blank" >http://dx.doi.org/10.1038/s41467-018-04076-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41467-018-04076-0" target="_blank" >10.1038/s41467-018-04076-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The human V delta 2(+) T-cell compartment comprises distinct innate-like V gamma 9(+) and adaptive V gamma 9(-) subsets

Popis výsledku v původním jazyce

V delta 2(+) T cells form the predominant human gamma delta T-cell population in peripheral blood and mediate T-cell receptor (TCR)-dependent anti-microbial and anti-tumour immunity. Here we show that the V delta 2(+) compartment comprises both innate-like and adaptive subsets. V gamma 9(+) V delta 2(+) T cells display semi-invariant TCR repertoires, featuring public V gamma 9 TCR sequences equivalent in cord and adult blood. By contrast, we also identify a separate, V gamma 9(-) V delta 2(+) T-cell subset that typically has a CD27(hi)CCR7(+)CD28(+)IL-7R alpha(+) naive-like phenotype and a diverse TCR repertoire, however in response to viral infection, undergoes clonal expansion and differentiation to a CD27(lo)CD45RA(+)CX(3)CR1(+) granzymeA/B+ effector phenotype. Consistent with a function in solid tissue immunosurveillance, we detect human intrahepatic V gamma 9(-) V delta 2(+) T cells featuring dominant clonal expansions and an effector phenotype. These findings redefine human delta d T-cell subsets by delineating the V delta 2(+) T-cell compartment into innate-like (V gamma 9(+)) and adaptive (V gamma 9(-)) subsets, which have distinct functions in microbial immunosurveillance.

Název v anglickém jazyce

The human V delta 2(+) T-cell compartment comprises distinct innate-like V gamma 9(+) and adaptive V gamma 9(-) subsets

Popis výsledku anglicky

V delta 2(+) T cells form the predominant human gamma delta T-cell population in peripheral blood and mediate T-cell receptor (TCR)-dependent anti-microbial and anti-tumour immunity. Here we show that the V delta 2(+) compartment comprises both innate-like and adaptive subsets. V gamma 9(+) V delta 2(+) T cells display semi-invariant TCR repertoires, featuring public V gamma 9 TCR sequences equivalent in cord and adult blood. By contrast, we also identify a separate, V gamma 9(-) V delta 2(+) T-cell subset that typically has a CD27(hi)CCR7(+)CD28(+)IL-7R alpha(+) naive-like phenotype and a diverse TCR repertoire, however in response to viral infection, undergoes clonal expansion and differentiation to a CD27(lo)CD45RA(+)CX(3)CR1(+) granzymeA/B+ effector phenotype. Consistent with a function in solid tissue immunosurveillance, we detect human intrahepatic V gamma 9(-) V delta 2(+) T cells featuring dominant clonal expansions and an effector phenotype. These findings redefine human delta d T-cell subsets by delineating the V delta 2(+) T-cell compartment into innate-like (V gamma 9(+)) and adaptive (V gamma 9(-)) subsets, which have distinct functions in microbial immunosurveillance.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Communications

ISSN

2041-1723

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

MAY

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

1760

Kód UT WoS článku

000431206400001

EID výsledku v databázi Scopus

2-s2.0-85046489750