Is IL-1 beta Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00106680" target="_blank" >RIV/00216224:14740/18:00106680 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3389/fcimb.2018.00272" target="_blank" >http://dx.doi.org/10.3389/fcimb.2018.00272</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fcimb.2018.00272" target="_blank" >10.3389/fcimb.2018.00272</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Is IL-1 beta Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris

Popis výsledku v původním jazyce

The pathogenesis of degenerative disc disease is a complex and multifactorial process in which genetics, mechanical trauma, altered loading and nutrition present significant etiological factors. Infection of the intervertebral disc with the anaerobic bacterium Propionibacteriumacnes is now also emerging as a potentially new etiological factor. This human commensal bacterium is well known for its long association with the inflammatory skin condition acne vulgaris. A key component of inflammatory responses to P. acnes in acne appears to be interleukin (IL)-1 beta. Similarly, in degenerative disc disease (DDD) there is compelling evidence for the fundamental roles of IL-1 beta in its pathology. We therefore propose that P. acnes involvement in DDD is biologically very plausible, and that IL-1 beta is the key inflammatory mechanism driving the host response to P. acnes infection. Since there is a solid theoretical basis for this phenomenon, we further propose that the relationship between P. acnes infection and DDD is causal.

Název v anglickém jazyce

Is IL-1 beta Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris

Popis výsledku anglicky

The pathogenesis of degenerative disc disease is a complex and multifactorial process in which genetics, mechanical trauma, altered loading and nutrition present significant etiological factors. Infection of the intervertebral disc with the anaerobic bacterium Propionibacteriumacnes is now also emerging as a potentially new etiological factor. This human commensal bacterium is well known for its long association with the inflammatory skin condition acne vulgaris. A key component of inflammatory responses to P. acnes in acne appears to be interleukin (IL)-1 beta. Similarly, in degenerative disc disease (DDD) there is compelling evidence for the fundamental roles of IL-1 beta in its pathology. We therefore propose that P. acnes involvement in DDD is biologically very plausible, and that IL-1 beta is the key inflammatory mechanism driving the host response to P. acnes infection. Since there is a solid theoretical basis for this phenomenon, we further propose that the relationship between P. acnes infection and DDD is causal.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

ISSN

2235-2988

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

AUG

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

272

Kód UT WoS článku

000441660900001

EID výsledku v databázi Scopus

2-s2.0-85052298313