Current Computational Approaches for the Development of Anti-HIV Inhibitors: An Overview

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F19%3A00113284" target="_blank" >RIV/00216224:14740/19:00113284 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.2174/1381612825666190911160244" target="_blank" >http://dx.doi.org/10.2174/1381612825666190911160244</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1381612825666190911160244" target="_blank" >10.2174/1381612825666190911160244</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Current Computational Approaches for the Development of Anti-HIV Inhibitors: An Overview

Popis výsledku v původním jazyce

Background: Today, HIV-1 infection has become an extensive problem to public health and a greater challenge to all working researchers throughout the world. Since the beginning of HIV-1 virus, several antiviral therapeutic agents have been developed at various stages to combat HIV-1 infection. But, the many of antiviral drugs are on the platform of drug resistance and toxicology issues, needs an urgent constructive investigation for the development of productive and protective therapeutics to make an improvement of individual life suffering with viral infection. As developing a novel agent is very costly, challenging and time taking route in the recent times. Methods: The review summarized about the modern approaches of computational aided drug discovery to developing a novel inhibitor within a short period of time and less cost. Results: The outcome suggests on the premise of reported information that the computational drug discovery is a powerful technology to design a defensive and fruitful therapeutic agents to combat HIV-1 infection and recover the lifespan of suffering one. Conclusion: Based on survey of the reported information, we concluded that the current computational approaches is highly supportive in the progress of drug discovery and controlling the viral infection.

Název v anglickém jazyce

Current Computational Approaches for the Development of Anti-HIV Inhibitors: An Overview

Popis výsledku anglicky

Background: Today, HIV-1 infection has become an extensive problem to public health and a greater challenge to all working researchers throughout the world. Since the beginning of HIV-1 virus, several antiviral therapeutic agents have been developed at various stages to combat HIV-1 infection. But, the many of antiviral drugs are on the platform of drug resistance and toxicology issues, needs an urgent constructive investigation for the development of productive and protective therapeutics to make an improvement of individual life suffering with viral infection. As developing a novel agent is very costly, challenging and time taking route in the recent times. Methods: The review summarized about the modern approaches of computational aided drug discovery to developing a novel inhibitor within a short period of time and less cost. Results: The outcome suggests on the premise of reported information that the computational drug discovery is a powerful technology to design a defensive and fruitful therapeutic agents to combat HIV-1 infection and recover the lifespan of suffering one. Conclusion: Based on survey of the reported information, we concluded that the current computational approaches is highly supportive in the progress of drug discovery and controlling the viral infection.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Pharmaceutical Design

ISSN

1381-6128

e-ISSN

—

Svazek periodika

25

Číslo periodika v rámci svazku

31

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

16

Strana od-do

3390-3405

Kód UT WoS článku

000496934200010

EID výsledku v databázi Scopus

2-s2.0-85075814376