What will studies of Fulani individuals naturally exposed to malaria teach us about protective immunity to malaria?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F20%3A00118368" target="_blank" >RIV/00216224:14740/20:00118368 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/sji.12932" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/sji.12932</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/sji.12932" target="_blank" >10.1111/sji.12932</a>

Jazyk výsledku

angličtina

Název v původním jazyce

What will studies of Fulani individuals naturally exposed to malaria teach us about protective immunity to malaria?

Popis výsledku v původním jazyce

There are an estimated over 200 million yearly cases of malaria worldwide. Despite concerted international effort to combat the disease, it still causes approximately half a million deaths every year, the majority of which are young children withPlasmodium falciparuminfection in sub-Saharan Africa. Successes are largely attributed to malaria prevention strategies, such as insecticide-treated mosquito nets and indoor spraying, as well as improved access to existing treatments. One important hurdle to new approaches for the treatment and prevention of malaria is our limited understanding of the biology ofPlasmodiuminfection and its complex interaction with the immune system of its human host. Therefore, the elimination of malaria in Africa not only relies on existing tools to reduce malaria burden, but also requires fundamental research to develop innovative approaches. Here, we summarize our discoveries from investigations of ethnic groups of West Africa who have different susceptibility to malaria.

Název v anglickém jazyce

What will studies of Fulani individuals naturally exposed to malaria teach us about protective immunity to malaria?

Popis výsledku anglicky

There are an estimated over 200 million yearly cases of malaria worldwide. Despite concerted international effort to combat the disease, it still causes approximately half a million deaths every year, the majority of which are young children withPlasmodium falciparuminfection in sub-Saharan Africa. Successes are largely attributed to malaria prevention strategies, such as insecticide-treated mosquito nets and indoor spraying, as well as improved access to existing treatments. One important hurdle to new approaches for the treatment and prevention of malaria is our limited understanding of the biology ofPlasmodiuminfection and its complex interaction with the immune system of its human host. Therefore, the elimination of malaria in Africa not only relies on existing tools to reduce malaria burden, but also requires fundamental research to develop innovative approaches. Here, we summarize our discoveries from investigations of ethnic groups of West Africa who have different susceptibility to malaria.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scandinavian journal of immunology

ISSN

0300-9475

e-ISSN

—

Svazek periodika

92

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

12932

Kód UT WoS článku

000576528300014

EID výsledku v databázi Scopus

2-s2.0-85091888881