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Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F20%3A00124448" target="_blank" >RIV/00216224:14740/20:00124448 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00023752:_____/22:43920518 RIV/00216208:11120/22:43920765 RIV/00216208:11130/22:10418890 RIV/00216224:14740/22:00125564

  • Výsledek na webu

    <a href="https://www.cambridge.org/core/journals/psychological-medicine/article/socioeconomic-deprivation-in-early-life-and-symptoms-of-depression-and-anxiety-in-young-adulthood-mediating-role-of-hippocampal-connectivity/389D84B5689593935017EA38FA905E44" target="_blank" >https://www.cambridge.org/core/journals/psychological-medicine/article/socioeconomic-deprivation-in-early-life-and-symptoms-of-depression-and-anxiety-in-young-adulthood-mediating-role-of-hippocampal-connectivity/389D84B5689593935017EA38FA905E44</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1017/S0033291720004754" target="_blank" >10.1017/S0033291720004754</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity

  • Popis výsledku v původním jazyce

    Background Experience of early-life socioeconomic deprivation (ELSD) may increase the risk of mental disorders in young adulthood. This association may be mediated by structural and functional alterations of the hippocampus. Methods We conducted a prospective cohort study on 122 participants of the European Longitudinal Study of Pregnancy and Childhood. Information about ELSD was collected via questionnaire from mothers during the first 18 months of participants' lives. At age 23-24, participants underwent examination by structural magnetic resonance imaging, resting-state functional connectivity and assessment of depressive symptoms (Mood and Feelings Questionnaire) and anxiety (Spielberger State-Trait Anxiety Inventory). The association of ELSD with brain outcomes in young adulthood was assessed with correlations, linear regression (adjusting for sex, socioeconomic position and mother's mental health) and moderated mediation analysis. Results Higher ELSD was associated with greater depressive symptoms (B = 0.22; p = 0.001), trait anxiety (B = 0.07; p = 0.02) and lower global connectivity of the right hippocampus (B =-0.01; p = 0.02). These associations persisted when adjusted for covariates. In women, lower global connectivity of the right hippocampus was associated with stronger trait anxiety (B =-4.14; p = 0.01). Global connectivity of the right hippocampus as well as connectivity between the right hippocampus and the left middle temporal gyrus mediated the association between ELSD and trait anxiety in women. Higher ELSD correlated with a lower volume of the right hippocampus in men, but the volume of the right hippocampus was not related to mental health. Conclusions Early preventive strategies targeted at children from socioeconomically deprived families may yield long-lasting benefits for the mental health of the population. © 2020 The Author(s). Published by Cambridge University Press.

  • Název v anglickém jazyce

    Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity

  • Popis výsledku anglicky

    Background Experience of early-life socioeconomic deprivation (ELSD) may increase the risk of mental disorders in young adulthood. This association may be mediated by structural and functional alterations of the hippocampus. Methods We conducted a prospective cohort study on 122 participants of the European Longitudinal Study of Pregnancy and Childhood. Information about ELSD was collected via questionnaire from mothers during the first 18 months of participants' lives. At age 23-24, participants underwent examination by structural magnetic resonance imaging, resting-state functional connectivity and assessment of depressive symptoms (Mood and Feelings Questionnaire) and anxiety (Spielberger State-Trait Anxiety Inventory). The association of ELSD with brain outcomes in young adulthood was assessed with correlations, linear regression (adjusting for sex, socioeconomic position and mother's mental health) and moderated mediation analysis. Results Higher ELSD was associated with greater depressive symptoms (B = 0.22; p = 0.001), trait anxiety (B = 0.07; p = 0.02) and lower global connectivity of the right hippocampus (B =-0.01; p = 0.02). These associations persisted when adjusted for covariates. In women, lower global connectivity of the right hippocampus was associated with stronger trait anxiety (B =-4.14; p = 0.01). Global connectivity of the right hippocampus as well as connectivity between the right hippocampus and the left middle temporal gyrus mediated the association between ELSD and trait anxiety in women. Higher ELSD correlated with a lower volume of the right hippocampus in men, but the volume of the right hippocampus was not related to mental health. Conclusions Early preventive strategies targeted at children from socioeconomically deprived families may yield long-lasting benefits for the mental health of the population. © 2020 The Author(s). Published by Cambridge University Press.

Klasifikace

  • Druh

    J<sub>SC</sub> - Článek v periodiku v databázi SCOPUS

  • CEP obor

  • OECD FORD obor

    30103 - Neurosciences (including psychophysiology)

Návaznosti výsledku

  • Projekt

    Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Psychological Medicine

  • ISSN

    0033-2917

  • e-ISSN

  • Svazek periodika

    2020

  • Číslo periodika v rámci svazku

    2020

  • Stát vydavatele periodika

    GB - Spojené království Velké Británie a Severního Irska

  • Počet stran výsledku

    10

  • Strana od-do

    1-10

  • Kód UT WoS článku

  • EID výsledku v databázi Scopus

    2-s2.0-85098200562