Sex differences in brain atrophy in dementia with Lewy bodies
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F23%3A00133508" target="_blank" >RIV/00216224:14740/23:00133508 - isvavai.cz</a>
Výsledek na webu
<a href="https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.13571" target="_blank" >https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.13571</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/alz.13571" target="_blank" >10.1002/alz.13571</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Sex differences in brain atrophy in dementia with Lewy bodies
Popis výsledku v původním jazyce
INTRODUCTIONSex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI).METHODSWe included 436 patients from the European-DLB consortium and the Mayo Clinic. Sex differences and sex-by-age interactions were assessed through visual atrophy rating scales (n = 327; 73 +/- 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 +/- 9 years, 72% males).RESULTSWe found a higher likelihood of frontal atrophy and smaller volumes in six cortical regions in males and thinner olfactory cortices in females. There were significant sex-by-age interactions in volume (six regions) and cortical thickness (seven regions) across the entire cortex.DISCUSSIONWe demonstrate that males have more widespread cortical atrophy at younger ages, but differences tend to disappear with increasing age, with males and females converging around the age of 75.HighlightsMale DLB patients had higher odds for frontal atrophy on radiological visual rating scales.Male DLB patients displayed a widespread pattern of cortical gray matter alterations on automated methods.Sex differences in gray matter measures in DLB tended to disappear with increasing age.
Název v anglickém jazyce
Sex differences in brain atrophy in dementia with Lewy bodies
Popis výsledku anglicky
INTRODUCTIONSex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI).METHODSWe included 436 patients from the European-DLB consortium and the Mayo Clinic. Sex differences and sex-by-age interactions were assessed through visual atrophy rating scales (n = 327; 73 +/- 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 +/- 9 years, 72% males).RESULTSWe found a higher likelihood of frontal atrophy and smaller volumes in six cortical regions in males and thinner olfactory cortices in females. There were significant sex-by-age interactions in volume (six regions) and cortical thickness (seven regions) across the entire cortex.DISCUSSIONWe demonstrate that males have more widespread cortical atrophy at younger ages, but differences tend to disappear with increasing age, with males and females converging around the age of 75.HighlightsMale DLB patients had higher odds for frontal atrophy on radiological visual rating scales.Male DLB patients displayed a widespread pattern of cortical gray matter alterations on automated methods.Sex differences in gray matter measures in DLB tended to disappear with increasing age.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30210 - Clinical neurology
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
ALZHEIMERS & DEMENTIA
ISSN
1552-5260
e-ISSN
1552-5279
Svazek periodika
20
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
12
Strana od-do
1815-1826
Kód UT WoS článku
001129490000001
EID výsledku v databázi Scopus
2-s2.0-85180259158