Translation control and co-translational processes in health and disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F24%3A00137991" target="_blank" >RIV/00216224:14740/24:00137991 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/23:00132412

Výsledek na webu

<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/48/87" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/48/87</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Translation control and co-translational processes in health and disease

Popis výsledku v původním jazyce

Co-translational quality control is triggered as aresponse to translational stalling events. Yet, different molecular mechanisms are employed for the recognition of these stalls and to trigger downstream rescue and quality control pathways. While the recognition of individual stalled ribosomes is poorly understood, the use of collided ribosomes as a proxy for the recognition of translation problems in the cell is conserved from bacteria to humans1–3. In eukaryotes, co-translational quality-control processes triggered by ribosome collisions accomplish several tasks and eventually trigger stress response signalling pathways. grated stress response (ISR) is a highly conserved eukaryotic mechanism for integrating multiple signals to reprogram gene expression. These signals are conveyed by protein kinases that phosphorylate the α subunit of the initiation factor 2 (eIF2). Mammals have four known eIF2α kinases: GCN2, PERK, HRI, and PKR, which are activated in response to amino-acid starvation, ER stress, cytoplasmic protein misfolding and viral infection, respectively.

Název v anglickém jazyce

Translation control and co-translational processes in health and disease

Popis výsledku anglicky

Co-translational quality control is triggered as aresponse to translational stalling events. Yet, different molecular mechanisms are employed for the recognition of these stalls and to trigger downstream rescue and quality control pathways. While the recognition of individual stalled ribosomes is poorly understood, the use of collided ribosomes as a proxy for the recognition of translation problems in the cell is conserved from bacteria to humans1–3. In eukaryotes, co-translational quality-control processes triggered by ribosome collisions accomplish several tasks and eventually trigger stress response signalling pathways. grated stress response (ISR) is a highly conserved eukaryotic mechanism for integrating multiple signals to reprogram gene expression. These signals are conveyed by protein kinases that phosphorylate the α subunit of the initiation factor 2 (eIF2). Mammals have four known eIF2α kinases: GCN2, PERK, HRI, and PKR, which are activated in response to amino-acid starvation, ER stress, cytoplasmic protein misfolding and viral infection, respectively.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů