Coactivation pattern analysis reveals changes in prodromal dementia with Lewy bodies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F24%3A00139982" target="_blank" >RIV/00216224:14740/24:00139982 - isvavai.cz</a>

Výsledek na webu

<a href="https://forum2024.fensforum.org/" target="_blank" >https://forum2024.fensforum.org/</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Coactivation pattern analysis reveals changes in prodromal dementia with Lewy bodies

Popis výsledku v původním jazyce

Dementia with Lewy body (DLB) builds significant part of synucleinopathies.Our aim is to study alterations in fMRI dynamic functional connectivity – Coactivation pattern analysis - characterizing prodromal stage of mild cognitive impairment with Lewy body (MCI-LB). CAP 4 is characterized with high activation in DMN, moderate activation in visual network and negative activation in FPCN. This pattern probably represents mind wandering, occurred during the measurement. Directly proportional relation of CAP 4 coverage with memory z-score in MCI-LB group suggests higher damage of memory function in MCI-LB participants who spent less time in this state. Observed results are in concordance with our observations on pilot data [4] and with results observed with sliding window analysis in state with positive correlation of DMN and visual network and negative correlation of DMN and FPCN. We plan to incorporate observed difference in classification model to test and validate, if brain dynamics can serve as imaging biomarker for MCI-LB.

Název v anglickém jazyce

Coactivation pattern analysis reveals changes in prodromal dementia with Lewy bodies

Popis výsledku anglicky

Dementia with Lewy body (DLB) builds significant part of synucleinopathies.Our aim is to study alterations in fMRI dynamic functional connectivity – Coactivation pattern analysis - characterizing prodromal stage of mild cognitive impairment with Lewy body (MCI-LB). CAP 4 is characterized with high activation in DMN, moderate activation in visual network and negative activation in FPCN. This pattern probably represents mind wandering, occurred during the measurement. Directly proportional relation of CAP 4 coverage with memory z-score in MCI-LB group suggests higher damage of memory function in MCI-LB participants who spent less time in this state. Observed results are in concordance with our observations on pilot data [4] and with results observed with sliding window analysis in state with positive correlation of DMN and visual network and negative correlation of DMN and FPCN. We plan to incorporate observed difference in classification model to test and validate, if brain dynamics can serve as imaging biomarker for MCI-LB.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NU21J-04-00077" target="_blank" >NU21J-04-00077: Využití dynamických parametrů funkční konektivity mozku jako diagnostického biomarkeru neurodegenerativních nemocí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů