How Argonautes engage with their protein binding partners
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F25%3A00143660" target="_blank" >RIV/00216224:14740/25:00143660 - isvavai.cz</a>
Výsledek na webu
<a href="https://argonautes.img.cas.cz/" target="_blank" >https://argonautes.img.cas.cz/</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
How Argonautes engage with their protein binding partners
Popis výsledku v původním jazyce
Argonaute proteins are central to small RNA-guided gene silencing and have long been known to associate with a variety of protein cofactors across pathways and organisms. However, only a limited number of these interactions have been directly validated, and high-resolution structural insights into how Argonautes engage with their protein partners–and how such interactions influence function–remain limited. In this talk, we will present our recent cryo-EM findings revealing two previously unrecognized modes of Argonaute-protein interaction, shedding light on how these contacts may modulate Argonaute conformation and activity.
Název v anglickém jazyce
How Argonautes engage with their protein binding partners
Popis výsledku anglicky
Argonaute proteins are central to small RNA-guided gene silencing and have long been known to associate with a variety of protein cofactors across pathways and organisms. However, only a limited number of these interactions have been directly validated, and high-resolution structural insights into how Argonautes engage with their protein partners–and how such interactions influence function–remain limited. In this talk, we will present our recent cryo-EM findings revealing two previously unrecognized modes of Argonaute-protein interaction, shedding light on how these contacts may modulate Argonaute conformation and activity.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
10608 - Biochemistry and molecular biology
Návaznosti výsledku
Projekt
<a href="/cs/project/EH22_008%2F0004575" target="_blank" >EH22_008/0004575: RNA pro terapii</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2025
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů