Sentence comprehension difficulties in Lewy body diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F25%3A00143676" target="_blank" >RIV/00216224:14740/25:00143676 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.eccn2025-london.com/" target="_blank" >https://www.eccn2025-london.com/</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Sentence comprehension difficulties in Lewy body diseases

Popis výsledku v původním jazyce

Lewy body diseases, including Parkinson’s disease (PD) and dementia with Lewy bodies, often involve mild cognitive impairment (MCI) at diagnosis (MCI-LB). Previously, we found that patients with PD without MCI have already a problem with sentence comprehension with altered task-dependent functional connectivity (Novakova et al. 2023). Our current aim was to assess syntactic comprehension deficits in MCI-LB patients and explore the neural correlates using functional connectivity analysis of the striatum and language networks. In ongoing second arm of this study, we aim to investigate the effects of repeated sessions of home-based tDCS on sentence comprehension. Our behavioural results showed disturbed sentence comprehension in MCI-LB patients with altered taskdependent functional connectivity from the striatum to the cuneus/precuneus/lingual gyrus and to left supramarginal gyrus. We found also decreased connectivity in language networks in MCI-LB patients. In noncanonical task it was specific for dorsal pathway, which is in line with literature that links syntax specifically to this dorsal language pathway.

Název v anglickém jazyce

Sentence comprehension difficulties in Lewy body diseases

Popis výsledku anglicky

Lewy body diseases, including Parkinson’s disease (PD) and dementia with Lewy bodies, often involve mild cognitive impairment (MCI) at diagnosis (MCI-LB). Previously, we found that patients with PD without MCI have already a problem with sentence comprehension with altered task-dependent functional connectivity (Novakova et al. 2023). Our current aim was to assess syntactic comprehension deficits in MCI-LB patients and explore the neural correlates using functional connectivity analysis of the striatum and language networks. In ongoing second arm of this study, we aim to investigate the effects of repeated sessions of home-based tDCS on sentence comprehension. Our behavioural results showed disturbed sentence comprehension in MCI-LB patients with altered taskdependent functional connectivity from the striatum to the cuneus/precuneus/lingual gyrus and to left supramarginal gyrus. We found also decreased connectivity in language networks in MCI-LB patients. In noncanonical task it was specific for dorsal pathway, which is in line with literature that links syntax specifically to this dorsal language pathway.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/EH23_025%2F0008726" target="_blank" >EH23_025/0008726: Celý život s jazykem: povaha a ontogeneze jazykové komunikace (LangInLife)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů