Interakce vanadocendichloridu s aminokyselinami obsahující síru

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F07%3A00006311" target="_blank" >RIV/00216275:25310/07:00006311 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Interaction of Antitumor Active Vanadocene Dichloride with Sulphur Containing Amino Acids

Popis výsledku v původním jazyce

Vanadocene dichloride (1) reacts with sulphur-containing amino acids, cysteine and methionine, giving new complexes with five- or six-membered chelate ring, but the structure of isolated compounds is affected by the pH value of the reaction mixture. Methionine reacts with aqueous 1 in the pH range of 3 - 8 affording chelate structure [Cp2V(N,O-met)]Cl (4). Similar reaction with cysteine gives two different products depending on pH. In the acidic solution, the complex [Cp2V(O,S-cys)]Cl (2) is present, but in neutral media the compound [Cp2V(N,S-cys)] (3) could be identified. On inspection of spectroscopic measurements, particularly EPR and vibrational spectroscopy, it is evident that sulphur atom of amino acid is bonded directly to the vanadium atom of[Cp2V]2+ moiety. For the purpose of comparison the complexes [Cp2V(O,S-mpa)] (5) and [Cp2V(N,S-csam)]+ (6a) with related chelating ligands, 3-mercaptopropionic acid (mpa) and cysteamine (csam), respectively, were prepared and spectroscopi

Název v anglickém jazyce

The Interaction of Antitumor Active Vanadocene Dichloride with Sulphur Containing Amino Acids

Popis výsledku anglicky

Vanadocene dichloride (1) reacts with sulphur-containing amino acids, cysteine and methionine, giving new complexes with five- or six-membered chelate ring, but the structure of isolated compounds is affected by the pH value of the reaction mixture. Methionine reacts with aqueous 1 in the pH range of 3 - 8 affording chelate structure [Cp2V(N,O-met)]Cl (4). Similar reaction with cysteine gives two different products depending on pH. In the acidic solution, the complex [Cp2V(O,S-cys)]Cl (2) is present, but in neutral media the compound [Cp2V(N,S-cys)] (3) could be identified. On inspection of spectroscopic measurements, particularly EPR and vibrational spectroscopy, it is evident that sulphur atom of amino acid is bonded directly to the vanadium atom of[Cp2V]2+ moiety. For the purpose of comparison the complexes [Cp2V(O,S-mpa)] (5) and [Cp2V(N,S-csam)]+ (6a) with related chelating ligands, 3-mercaptopropionic acid (mpa) and cysteamine (csam), respectively, were prepared and spectroscopi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Oranometallic Chemistry

ISSN

0022-328X

e-ISSN

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Svazek periodika

692

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

3758-3764

Kód UT WoS článku

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EID výsledku v databázi Scopus

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