The non-radioactive local lymph node assay: Skin sensitisation and irritation testing.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F09%3A00008567" target="_blank" >RIV/00216275:25310/09:00008567 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The non-radioactive local lymph node assay: Skin sensitisation and irritation testing.

Popis výsledku v původním jazyce

This study was performed to investigate whether alternative endpoints of the local lymph node assay, non radioactive (LLNA-nR) like the ear weight and count cells would give additional information about the sensitizing/irritating potential of a tested substance. The legislation of REACH prefers alternative testing for skin sensitization and irritation. We have performed classic testing methods for skin irritation, for skin sensitization and alternative method LLNAnR with verified skin sensitizers, skinirritants and with some compounds which were intended to be subjected to registration process according to REACH and other legislation rules. The aim of this paper was to test the hypothesis that it would be possible to use the LLNAnR testing method as single stand-alone method for the evaluation of sensitizing and irritation potential of untested chemicals. There is not only one test for simple determination of two skin toxicity endpoints, sensitization and skin irritation to date.

Název v anglickém jazyce

The non-radioactive local lymph node assay: Skin sensitisation and irritation testing.

Popis výsledku anglicky

This study was performed to investigate whether alternative endpoints of the local lymph node assay, non radioactive (LLNA-nR) like the ear weight and count cells would give additional information about the sensitizing/irritating potential of a tested substance. The legislation of REACH prefers alternative testing for skin sensitization and irritation. We have performed classic testing methods for skin irritation, for skin sensitization and alternative method LLNAnR with verified skin sensitizers, skinirritants and with some compounds which were intended to be subjected to registration process according to REACH and other legislation rules. The aim of this paper was to test the hypothesis that it would be possible to use the LLNAnR testing method as single stand-alone method for the evaluation of sensitizing and irritation potential of untested chemicals. There is not only one test for simple determination of two skin toxicity endpoints, sensitization and skin irritation to date.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Papers of the University of Pardubice, Series A

ISSN

1211-5541

e-ISSN

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Svazek periodika

15

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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