Effect of Substitution on the Antimycobacterial Activity of 2-(Subst. Benzyl)sulfanyl Benzimidazoles, Benzoxazoles, and

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F11%3A39891994" target="_blank" >RIV/00216275:25310/11:39891994 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1248/cpb.59.179" target="_blank" >http://dx.doi.org/10.1248/cpb.59.179</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1248/cpb.59.179" target="_blank" >10.1248/cpb.59.179</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of Substitution on the Antimycobacterial Activity of 2-(Subst. Benzyl)sulfanyl Benzimidazoles, Benzoxazoles, and

Popis výsledku v původním jazyce

A set of 1160 MIC values evaluating effect of substitution on the antimycobacterial activity of the previously published 2-(subst. benzyl)sulfanyl benzimidazoles, benzoxazoles, and benzothiazoles has been analyzed by the methods of multidimensional . Theantimycobacterial activity increased in the order of BTZ{BOZ~BIM{5 Me-BIM. The sensitivity of particular strains towards these compounds decreased in the order of M. kansasii 6509/96, M. avium My 330/88, M. kansasii My 235/80, and M. tuberculosis My 331/88. The log MIC values depended with a negative slope on the Hammett substituent constants sigma or molar refractions MR and, for the given set of substituents, were dominantly raised with increasing log P value and partially lowered with (log P)2 or sigma xlog delta P. The derivatives featuring high polarizability, low lipophilicity and electron-withdrawing subtituents showed the highest antimycobacterial activity.

Název v anglickém jazyce

Effect of Substitution on the Antimycobacterial Activity of 2-(Subst. Benzyl)sulfanyl Benzimidazoles, Benzoxazoles, and

Popis výsledku anglicky

A set of 1160 MIC values evaluating effect of substitution on the antimycobacterial activity of the previously published 2-(subst. benzyl)sulfanyl benzimidazoles, benzoxazoles, and benzothiazoles has been analyzed by the methods of multidimensional . Theantimycobacterial activity increased in the order of BTZ{BOZ~BIM{5 Me-BIM. The sensitivity of particular strains towards these compounds decreased in the order of M. kansasii 6509/96, M. avium My 330/88, M. kansasii My 235/80, and M. tuberculosis My 331/88. The log MIC values depended with a negative slope on the Hammett substituent constants sigma or molar refractions MR and, for the given set of substituents, were dominantly raised with increasing log P value and partially lowered with (log P)2 or sigma xlog delta P. The derivatives featuring high polarizability, low lipophilicity and electron-withdrawing subtituents showed the highest antimycobacterial activity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA203%2F08%2F0208" target="_blank" >GA203/08/0208: Anorganicko-organické hybridní materiály na bázi organofosfonátů kovů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical and Pharmaceutical Bulletin

ISSN

0009-2363

e-ISSN

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Svazek periodika

59

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

6

Strana od-do

"179?184"

Kód UT WoS článku

000286863200006

EID výsledku v databázi Scopus

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