Eco-Synthesis of PVA/Chitosan Hydrogels for Biomedical Application

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F11%3A39892342" target="_blank" >RIV/00216275:25310/11:39892342 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s10924-011-0334-0" target="_blank" >http://dx.doi.org/10.1007/s10924-011-0334-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10924-011-0334-0" target="_blank" >10.1007/s10924-011-0334-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Eco-Synthesis of PVA/Chitosan Hydrogels for Biomedical Application

Popis výsledku v původním jazyce

A drug delivery system based on physically cross-linked poly vinyl alcohol (PVA)/chitosan blend hydrogels for the release of sparfloxacin antibiotic as a model for drugs was described. Eco-synthesis in current work is based on synthesizing a hydrogel without using chemical crosslinking agents like in the conventional method. In addition all materials are used are non- toxic, safe, non-carcinogenic and can be accepted by the human body without danger. The swelling behavior was tested to be dependent on pH as temperature as well as time and number of freezing thawing cycles. The physical properties of the hydrogels, such as swelling percent, dissolution percent, gel fraction and mechanical properties was assessed. The antimicrobial activity of hydrogelshaving different compositions was evaluated for both gram positive and gram negative bacteria. Furthermore, the release of antibiotic from hydrogels prepared using the freeze- thawed process was studied.

Název v anglickém jazyce

Eco-Synthesis of PVA/Chitosan Hydrogels for Biomedical Application

Popis výsledku anglicky

A drug delivery system based on physically cross-linked poly vinyl alcohol (PVA)/chitosan blend hydrogels for the release of sparfloxacin antibiotic as a model for drugs was described. Eco-synthesis in current work is based on synthesizing a hydrogel without using chemical crosslinking agents like in the conventional method. In addition all materials are used are non- toxic, safe, non-carcinogenic and can be accepted by the human body without danger. The swelling behavior was tested to be dependent on pH as temperature as well as time and number of freezing thawing cycles. The physical properties of the hydrogels, such as swelling percent, dissolution percent, gel fraction and mechanical properties was assessed. The antimicrobial activity of hydrogelshaving different compositions was evaluated for both gram positive and gram negative bacteria. Furthermore, the release of antibiotic from hydrogels prepared using the freeze- thawed process was studied.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Polymers and the Environment

ISSN

1566-2543

e-ISSN

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Svazek periodika

19

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

1005-1012

Kód UT WoS článku

000297370100022

EID výsledku v databázi Scopus

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