Effects of functional monomers on retention behavior of small and large molecules in monolithic capillary columns at isocratic and gradient conditions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F11%3A39892629" target="_blank" >RIV/00216275:25310/11:39892629 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jssc.201100174" target="_blank" >http://dx.doi.org/10.1002/jssc.201100174</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jssc.201100174" target="_blank" >10.1002/jssc.201100174</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of functional monomers on retention behavior of small and large molecules in monolithic capillary columns at isocratic and gradient conditions

Popis výsledku v původním jazyce

The polarity of (poly)methacrylate monolithic capillary columns was varied by using alkylmethacrylate monomers with butyl, cyclohexyl, 2-ethylhexyl, lauryl, and stearyl functional groups in the polymerization mixture. The hydrodynamic properties, as wellas the retention characteristics in RP-LC of small molecules (alkylbenzenes) and of proteins under gradient elution conditions were studied. The RP selectivity depends on the type of alkyl chain in methacrylate monomer; however, there was no direct correlation between the size of the monomer molecule and methylene or aromatic selectivity of the monlithic column. The lowest selectivity was found for column based on lauryl methacrylate monomer. On the other hand, butyl methacrylate column shows high phenyl selektivity and the column with stearyl methacrylate possesses the highest methylene selectivity for small molecules.

Název v anglickém jazyce

Effects of functional monomers on retention behavior of small and large molecules in monolithic capillary columns at isocratic and gradient conditions

Popis výsledku anglicky

The polarity of (poly)methacrylate monolithic capillary columns was varied by using alkylmethacrylate monomers with butyl, cyclohexyl, 2-ethylhexyl, lauryl, and stearyl functional groups in the polymerization mixture. The hydrodynamic properties, as wellas the retention characteristics in RP-LC of small molecules (alkylbenzenes) and of proteins under gradient elution conditions were studied. The RP selectivity depends on the type of alkyl chain in methacrylate monomer; however, there was no direct correlation between the size of the monomer molecule and methylene or aromatic selectivity of the monlithic column. The lowest selectivity was found for column based on lauryl methacrylate monomer. On the other hand, butyl methacrylate column shows high phenyl selektivity and the column with stearyl methacrylate possesses the highest methylene selectivity for small molecules.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/GA203%2F07%2F0641" target="_blank" >GA203/07/0641: Nové analytické postupy v kombinovaných fázových systémech s vysokou separační kapacitou</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Separation Science

ISSN

1615-9306

e-ISSN

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Svazek periodika

34

Číslo periodika v rámci svazku

16

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

2054-2062

Kód UT WoS článku

000295189400012

EID výsledku v databázi Scopus

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