a-Amino acid-derived 2-phenylimidazoles with potential antimycobacterial activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39894592" target="_blank" >RIV/00216275:25310/12:39894592 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.2478/s11532-012-0087-1" target="_blank" >http://dx.doi.org/10.2478/s11532-012-0087-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11532-012-0087-1" target="_blank" >10.2478/s11532-012-0087-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

a-Amino acid-derived 2-phenylimidazoles with potential antimycobacterial activity

Popis výsledku v původním jazyce

alfa-Amino acid-derived 2-phenylimidazole derivatives were designed, synthesized, and further investigated as potential antimycobacterial agents. The synthesis of target imidazole derivatives involved the transformation of Cbz-protected alfa-amino acids(Ala, Val, Phe, Leu, iLe, and Pro) into alfa-diazoketones and alfa-bromoketones, respectively. Subsequent treatment of alfa-bromoketones with (4-nitro) benzamidine afforded imidazole derivatives bearing alfa-amino acid residue appended to the imidazole C4 and (4-nitro)phenyl ring in the position C2. Antimycobacterial activities of both series of compounds against M. tuberculosis, M. avium, and M. kansasii were screened and basic structure-activity relationships were further evaluated.

Název v anglickém jazyce

a-Amino acid-derived 2-phenylimidazoles with potential antimycobacterial activity

Popis výsledku anglicky

alfa-Amino acid-derived 2-phenylimidazole derivatives were designed, synthesized, and further investigated as potential antimycobacterial agents. The synthesis of target imidazole derivatives involved the transformation of Cbz-protected alfa-amino acids(Ala, Val, Phe, Leu, iLe, and Pro) into alfa-diazoketones and alfa-bromoketones, respectively. Subsequent treatment of alfa-bromoketones with (4-nitro) benzamidine afforded imidazole derivatives bearing alfa-amino acid residue appended to the imidazole C4 and (4-nitro)phenyl ring in the position C2. Antimycobacterial activities of both series of compounds against M. tuberculosis, M. avium, and M. kansasii were screened and basic structure-activity relationships were further evaluated.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Central European Journal of Chemistry

ISSN

1895-1066

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

7

Strana od-do

1681-1687

Kód UT WoS článku

000306695700033

EID výsledku v databázi Scopus

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