Antibodies against Carbonic Anhydrase in Patients with Aplastic Anemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39895323" target="_blank" >RIV/00216275:25310/12:39895323 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1159/000338826" target="_blank" >http://dx.doi.org/10.1159/000338826</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000338826" target="_blank" >10.1159/000338826</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antibodies against Carbonic Anhydrase in Patients with Aplastic Anemia

Popis výsledku v původním jazyce

Antibodies against carbonic anhydrase (CA) have been detected in patients with an aplastic anemia (AA)-like syndrome after autologous stem cell transplantation. We analyzed sera of 53 bona fide AA patients before and after treatment with anti-thymocyte globulin (ATG) or bone marrow transplantation for the presence of anti-CA antibodies. Anti-CA antibodies were detected in 20 patients (38%) and were associated with older age at diagnosis of AA. Antibody-positive patients showed poor response to ATG treatment (complete response 14%) and inferior long-term survival (36% at 10 years), when compared to antibody-negative patients (complete response and 10-year survival both 64%). Two thirds of patients with antibodies at diagnosis of AA became antibody negative after treatment with ATG. Clearance of the antibody did not appear to be associated with hematological improvement. Antibodies against CA are detected frequently at diagnosis of AA, and their presence identifies a subset of patients w

Název v anglickém jazyce

Antibodies against Carbonic Anhydrase in Patients with Aplastic Anemia

Popis výsledku anglicky

Antibodies against carbonic anhydrase (CA) have been detected in patients with an aplastic anemia (AA)-like syndrome after autologous stem cell transplantation. We analyzed sera of 53 bona fide AA patients before and after treatment with anti-thymocyte globulin (ATG) or bone marrow transplantation for the presence of anti-CA antibodies. Anti-CA antibodies were detected in 20 patients (38%) and were associated with older age at diagnosis of AA. Antibody-positive patients showed poor response to ATG treatment (complete response 14%) and inferior long-term survival (36% at 10 years), when compared to antibody-negative patients (complete response and 10-year survival both 64%). Two thirds of patients with antibodies at diagnosis of AA became antibody negative after treatment with ATG. Clearance of the antibody did not appear to be associated with hematological improvement. Antibodies against CA are detected frequently at diagnosis of AA, and their presence identifies a subset of patients w

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/EE2.3.30.0021" target="_blank" >EE2.3.30.0021: Posílení excelentních týmů výzkumu a vývoje na Univerzitě Pardubice</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Haematologica

ISSN

0001-5792

e-ISSN

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Svazek periodika

128

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

5

Strana od-do

190-194

Kód UT WoS článku

000307875700011

EID výsledku v databázi Scopus

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