Biotransformation of Benzimidazole Anthelmintics in Reed (Phragmites australis) as a Potential Tool for their Detoxification in Environment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F13%3A39896255" target="_blank" >RIV/00216275:25310/13:39896255 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389030:_____/13:00399919 RIV/00216208:11160/13:10144276

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0960852413010341" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0960852413010341</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biortech.2013.06.105" target="_blank" >10.1016/j.biortech.2013.06.105</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biotransformation of Benzimidazole Anthelmintics in Reed (Phragmites australis) as a Potential Tool for their Detoxification in Environment

Popis výsledku v původním jazyce

Benzimidazole anthelmintics, the drugs against parasitic worms, are widely used in human as well as veterinary medicine. Following excretion, these substances may persist in the environment and impact non-target organisms. In order to test phytoremediation as a possible tool for detoxification of anthelmintics in environment, the biotransformation pathways of albendazole (ABZ) and flubendazole (FLU) were studied in reed (Phragmites australis) in vitro. Reed cells were able to uptake and biotransform both anthelmintics. Ten ABZ metabolites and five FLU metabolites were found. Some atypical biotransformation reactions (formation of glucosylglucosides, acetylglucosides and xylosylglucosides), which have not been described previously, were identified. Based on the obtained results, the schemes of metabolic pathways of ABZ and FLU in reed were proposed. Most of ABZ and FLU metabolites can be considered as anthelmintically less active; therefore uptake and biotransformation of these anthelmi

Název v anglickém jazyce

Biotransformation of Benzimidazole Anthelmintics in Reed (Phragmites australis) as a Potential Tool for their Detoxification in Environment

Popis výsledku anglicky

Benzimidazole anthelmintics, the drugs against parasitic worms, are widely used in human as well as veterinary medicine. Following excretion, these substances may persist in the environment and impact non-target organisms. In order to test phytoremediation as a possible tool for detoxification of anthelmintics in environment, the biotransformation pathways of albendazole (ABZ) and flubendazole (FLU) were studied in reed (Phragmites australis) in vitro. Reed cells were able to uptake and biotransform both anthelmintics. Ten ABZ metabolites and five FLU metabolites were found. Some atypical biotransformation reactions (formation of glucosylglucosides, acetylglucosides and xylosylglucosides), which have not been described previously, were identified. Based on the obtained results, the schemes of metabolic pathways of ABZ and FLU in reed were proposed. Most of ABZ and FLU metabolites can be considered as anthelmintically less active; therefore uptake and biotransformation of these anthelmi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bioresource Technology

ISSN

0960-8524

e-ISSN

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Svazek periodika

144

Číslo periodika v rámci svazku

september

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

216-224

Kód UT WoS článku

000324280100031

EID výsledku v databázi Scopus

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