PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898116" target="_blank" >RIV/00216275:25310/14:39898116 - isvavai.cz</a>
Výsledek na webu
<a href="http://download.springer.com/static/pdf/98/art%253A10.1007%252Fs00125-014-3310-0.pdf?auth66=1418981818_714d2c604725b6077692eb98fc804e20&ext=.pdf" target="_blank" >http://download.springer.com/static/pdf/98/art%253A10.1007%252Fs00125-014-3310-0.pdf?auth66=1418981818_714d2c604725b6077692eb98fc804e20&ext=.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00125-014-3310-0" target="_blank" >10.1007/s00125-014-3310-0</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans
Popis výsledku v původním jazyce
Aims/hypothesis The common sequence variant I148M of the patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) is associated with increased hepatic triacylglycerol (TAG) content, but not with insulin resistance, in humans. The PNPLA3(I148M) variant was previously reported to alter the specificity of the encoded enzyme and subsequently affect lipid composition. Methods We analysed the fatty acid composition of five lipid fractions from liver tissue samples from 52 individuals, including 19carriers of the minor PNPLA3(I148M) variant. Results PNPLA3(I148M) was associated with a strong increase (1.75-fold) in liver TAGs, but with no change in other lipid fractions. PNPLA3(I148M) minor allele carriers had an increased n-3 polyunsaturated fatty acid (PUFA) alpha-linolenic acid content and reductions in several n-6 PUFAs in the liver TAG fraction. Furthermore, there was a strong inverse correlation between n-6 PUFA and TAG content independent of PNPLA3 genotype. In a multivari
Název v anglickém jazyce
PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans
Popis výsledku anglicky
Aims/hypothesis The common sequence variant I148M of the patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) is associated with increased hepatic triacylglycerol (TAG) content, but not with insulin resistance, in humans. The PNPLA3(I148M) variant was previously reported to alter the specificity of the encoded enzyme and subsequently affect lipid composition. Methods We analysed the fatty acid composition of five lipid fractions from liver tissue samples from 52 individuals, including 19carriers of the minor PNPLA3(I148M) variant. Results PNPLA3(I148M) was associated with a strong increase (1.75-fold) in liver TAGs, but with no change in other lipid fractions. PNPLA3(I148M) minor allele carriers had an increased n-3 polyunsaturated fatty acid (PUFA) alpha-linolenic acid content and reductions in several n-6 PUFAs in the liver TAG fraction. Furthermore, there was a strong inverse correlation between n-6 PUFA and TAG content independent of PNPLA3 genotype. In a multivari
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Diabetologia
ISSN
0012-186X
e-ISSN
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Svazek periodika
57
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
5
Strana od-do
2103-2107
Kód UT WoS článku
000341708900012
EID výsledku v databázi Scopus
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