Degradation study of nitroaromatic explosives 2-diazo-4,6-dinitrophenol and picramic acid using HPLC and UHPLC-ESI-MS/MS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898721" target="_blank" >RIV/00216275:25310/14:39898721 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/14:10281874

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c4ay00401a" target="_blank" >http://dx.doi.org/10.1039/c4ay00401a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c4ay00401a" target="_blank" >10.1039/c4ay00401a</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Degradation study of nitroaromatic explosives 2-diazo-4,6-dinitrophenol and picramic acid using HPLC and UHPLC-ESI-MS/MS

Popis výsledku v původním jazyce

A new and fast HPLC method with UV detection was developed and validated for the simultaneous determination of nitroaromatic explosives diazodinitrophenol (DDNP), the raw material picramic acid (PicA) and three degradation products of DDNP. DDNP and PicAwere subjected to forced degradation. DDNP was found to be stable under acidic and basic conditions, while thermal, oxidative and photolytic decomposition resulted in three degradation products. Degradation products were separated from DDNP using Ascentis(R) Express C18 fused core particle column and subsequently characterised using UHPLC-ESI-MS/MS method. Optimal chromatography was performed using the isocratic elution of mobile phase consisting of acetonitrile-orthophosphoric acid 0.085% 30 : 70 (v/v) pumped at a flow rate of 0.8 mL/min at a temperature of 50°C. System suitability test parameters, linearity and precision of the HPLC method were evaluated. The new HPLC method is suitable for a fast determination of DDNP and degradatio

Název v anglickém jazyce

Degradation study of nitroaromatic explosives 2-diazo-4,6-dinitrophenol and picramic acid using HPLC and UHPLC-ESI-MS/MS

Popis výsledku anglicky

A new and fast HPLC method with UV detection was developed and validated for the simultaneous determination of nitroaromatic explosives diazodinitrophenol (DDNP), the raw material picramic acid (PicA) and three degradation products of DDNP. DDNP and PicAwere subjected to forced degradation. DDNP was found to be stable under acidic and basic conditions, while thermal, oxidative and photolytic decomposition resulted in three degradation products. Degradation products were separated from DDNP using Ascentis(R) Express C18 fused core particle column and subsequently characterised using UHPLC-ESI-MS/MS method. Optimal chromatography was performed using the isocratic elution of mobile phase consisting of acetonitrile-orthophosphoric acid 0.085% 30 : 70 (v/v) pumped at a flow rate of 0.8 mL/min at a temperature of 50°C. System suitability test parameters, linearity and precision of the HPLC method were evaluated. The new HPLC method is suitable for a fast determination of DDNP and degradatio

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Analytical Methods

ISSN

1759-9660

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

13

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

4761-4768

Kód UT WoS článku

000337763200041

EID výsledku v databázi Scopus

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