Bioinorganic chemistry of vanadocene dichloride

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F15%3A39899624" target="_blank" >RIV/00216275:25310/15:39899624 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ica.2015.08.008" target="_blank" >http://dx.doi.org/10.1016/j.ica.2015.08.008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ica.2015.08.008" target="_blank" >10.1016/j.ica.2015.08.008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bioinorganic chemistry of vanadocene dichloride

Popis výsledku v původním jazyce

This review article summarizes the development in bioinorganic chemistry of vanadocene dichloride and its derivatives. It is focused mainly on studies related with biological activity appearing in past four decades, after the antitumor activity of bent metallocenes was discovered by Petra Kopf-Maier and Hartmut Kopf. The first part deals with the unique hydrolytic chemistry of vanadocene dichloride and the reactivity with biologically relevant molecules, necessary for understanding of its antitumor effect on the molecular level. The second part summarizes the results of in vitro and in vivo biological assays. It covers not only the experiments related with antitumor activity but also a series of studies focused on the spermicidal properties with uniquemechanism of action. A special attention is given to structure-activity studies on modified vanadocene compounds.

Název v anglickém jazyce

Bioinorganic chemistry of vanadocene dichloride

Popis výsledku anglicky

This review article summarizes the development in bioinorganic chemistry of vanadocene dichloride and its derivatives. It is focused mainly on studies related with biological activity appearing in past four decades, after the antitumor activity of bent metallocenes was discovered by Petra Kopf-Maier and Hartmut Kopf. The first part deals with the unique hydrolytic chemistry of vanadocene dichloride and the reactivity with biologically relevant molecules, necessary for understanding of its antitumor effect on the molecular level. The second part summarizes the results of in vitro and in vivo biological assays. It covers not only the experiments related with antitumor activity but also a series of studies focused on the spermicidal properties with uniquemechanism of action. A special attention is given to structure-activity studies on modified vanadocene compounds.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganica Chimica Acta

ISSN

0020-1693

e-ISSN

—

Svazek periodika

437

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

87-94

Kód UT WoS článku

000361938600014

EID výsledku v databázi Scopus

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