Antimicrobial effect of salicylamide derivatives against intestinal sulfate-reducing bacteria

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39901615" target="_blank" >RIV/00216275:25310/16:39901615 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16370/16:43874210

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jab.2016.01.005" target="_blank" >http://dx.doi.org/10.1016/j.jab.2016.01.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jab.2016.01.005" target="_blank" >10.1016/j.jab.2016.01.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antimicrobial effect of salicylamide derivatives against intestinal sulfate-reducing bacteria

Popis výsledku v původním jazyce

Sulfate-reducing bacteria (SRB) are most likely involved in both the initiation and maintenance of inflammatory bowel disease (IBD); unfortunately present antibacterial chemotherapeutics used in the treatment of IBD have been ineffective. Thus, the antimicrobial activity of salicylamide derivatives against two different genera of intestinal SRB, Desulfovibrio and Desulfomicrobium, was investigated. Six 2-(phenylcarbamoyl) phenyl N-[(benzyloxy)carbonyl] alkanoates and three 2-hydroxy-N-[(2S)-1-oxo-1-(phenylamino)alkan-2-yl]benzamides showed MIC values in the range from 0.22 to 0.35 mu M against Desulfovibrio piger Vib-7 and in the range from 0.27 to 8.52 mu M against Desulfomicrobium sp. Rod-9, while MIC values of ciprofloxacin were 41.2 mu M and 39.3 mu M. The highest potency against the two strains was observed for 4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-3-methyl-1-oxobutan-2-yl}-2-hydroxybenzamide (MIC 0.22 mu M and 0.27 mu M). 4-Chloro-2-[(4-nitrophenyl) carbamoyl]phenyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoate showed high activity against D. piger Vib-7 (MIC = 0.26 mu M), while 4-chloro-2-[(4-methylphenyl)carbamoyl]phenyl (2S)-2-[( tert-butoxycarbonyl)amino]-3-(1H-indol-2-yl) propanoate expressed high activity against Desulfomicrobium sp. Rod-9 (MIC = 0.31 mu M). Structure-activity relationships are discussed.

Název v anglickém jazyce

Antimicrobial effect of salicylamide derivatives against intestinal sulfate-reducing bacteria

Popis výsledku anglicky

Sulfate-reducing bacteria (SRB) are most likely involved in both the initiation and maintenance of inflammatory bowel disease (IBD); unfortunately present antibacterial chemotherapeutics used in the treatment of IBD have been ineffective. Thus, the antimicrobial activity of salicylamide derivatives against two different genera of intestinal SRB, Desulfovibrio and Desulfomicrobium, was investigated. Six 2-(phenylcarbamoyl) phenyl N-[(benzyloxy)carbonyl] alkanoates and three 2-hydroxy-N-[(2S)-1-oxo-1-(phenylamino)alkan-2-yl]benzamides showed MIC values in the range from 0.22 to 0.35 mu M against Desulfovibrio piger Vib-7 and in the range from 0.27 to 8.52 mu M against Desulfomicrobium sp. Rod-9, while MIC values of ciprofloxacin were 41.2 mu M and 39.3 mu M. The highest potency against the two strains was observed for 4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-3-methyl-1-oxobutan-2-yl}-2-hydroxybenzamide (MIC 0.22 mu M and 0.27 mu M). 4-Chloro-2-[(4-nitrophenyl) carbamoyl]phenyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoate showed high activity against D. piger Vib-7 (MIC = 0.26 mu M), while 4-chloro-2-[(4-methylphenyl)carbamoyl]phenyl (2S)-2-[( tert-butoxycarbonyl)amino]-3-(1H-indol-2-yl) propanoate expressed high activity against Desulfomicrobium sp. Rod-9 (MIC = 0.31 mu M). Structure-activity relationships are discussed.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/EE2.3.30.0053" target="_blank" >EE2.3.30.0053: Farmakotoxikologické hodnocení nově syntetizovaných (izolovaných) látek jako nástroj integrace preklinických disciplín na VFU Brno</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

125-130

Kód UT WoS článku

000373608500007

EID výsledku v databázi Scopus

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