A new sensing platform based on NH2fMWCNTs for the determination of antiarrhythmic drug Propafenone in pharmaceutical dosage forms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F19%3A39915141" target="_blank" >RIV/00216275:25310/19:39915141 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.jpba.2019.06.026" target="_blank" >https://doi.org/10.1016/j.jpba.2019.06.026</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jpba.2019.06.026" target="_blank" >10.1016/j.jpba.2019.06.026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A new sensing platform based on NH2fMWCNTs for the determination of antiarrhythmic drug Propafenone in pharmaceutical dosage forms

Popis výsledku v původním jazyce

A novel sensor based on a modification of glassy carbon electrode (GCE) with NH2-functionalized multi walled carbon nano-tubes (NH(2)fMWCNTs) is reported and its applicability to the electrochemical sensing of Propafenone (PPF) demonstrated. The electrochemical catalytic activity was also utilized as a sensitive detection method for the investigation of the detailed redox mechanism of PFF using cyclic and and differential pulse voltammetry. The surface morphology of the sensor was investigated by SEM armed with EDX probe. Electrochemical impedance spectroscopy was employed as well to define the electron transfer capability of modified and bare electrodes. Key experimental and instrumental conditions related to electrochemical determination by cyclic, differential pulse, and square wave voltammetry, such as amount of modifier, pH, scan rate, accumulation time and potential were studied and optimized. The results have shown a significant enhancement of the peak current after modifying the electrode; the calibration curves of PPF offering good linearity from 0.1 to 10 mu M, limit of quantification (LOQ) being 0.03 mu M and limit of detection (LOD) 0.01 mu M, both when using DPV technique. The proposed sensor was successfully applied to the determination of PFF in dosage form without any special purification, separation or pre-treatment steps. The results of analyses obtained with the proposed sensor were satisfactory and fully statistically relevant. (C) 2019 Elsevier B.V. All rights reserved.

Název v anglickém jazyce

A new sensing platform based on NH2fMWCNTs for the determination of antiarrhythmic drug Propafenone in pharmaceutical dosage forms

Popis výsledku anglicky

A novel sensor based on a modification of glassy carbon electrode (GCE) with NH2-functionalized multi walled carbon nano-tubes (NH(2)fMWCNTs) is reported and its applicability to the electrochemical sensing of Propafenone (PPF) demonstrated. The electrochemical catalytic activity was also utilized as a sensitive detection method for the investigation of the detailed redox mechanism of PFF using cyclic and and differential pulse voltammetry. The surface morphology of the sensor was investigated by SEM armed with EDX probe. Electrochemical impedance spectroscopy was employed as well to define the electron transfer capability of modified and bare electrodes. Key experimental and instrumental conditions related to electrochemical determination by cyclic, differential pulse, and square wave voltammetry, such as amount of modifier, pH, scan rate, accumulation time and potential were studied and optimized. The results have shown a significant enhancement of the peak current after modifying the electrode; the calibration curves of PPF offering good linearity from 0.1 to 10 mu M, limit of quantification (LOQ) being 0.03 mu M and limit of detection (LOD) 0.01 mu M, both when using DPV technique. The proposed sensor was successfully applied to the determination of PFF in dosage form without any special purification, separation or pre-treatment steps. The results of analyses obtained with the proposed sensor were satisfactory and fully statistically relevant. (C) 2019 Elsevier B.V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Pharmaceutical and Biomedical Analysis

ISSN

0731-7085

e-ISSN

—

Svazek periodika

174

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

534-540

Kód UT WoS článku

000479328000062

EID výsledku v databázi Scopus

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