Synthesis, molecular docking, antibacterial, and anti-inflammatory activities of benzimidazole-containing tricyclic systems

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F21%3A39917536" target="_blank" >RIV/00216275:25310/21:39917536 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.researchgate.net/publication/348810368_Synthesis_molecular_docking_antibacterial_and_anti-inflammatory_activities_of_benzimidazole-containing_tricyclic_systems" target="_blank" >https://www.researchgate.net/publication/348810368_Synthesis_molecular_docking_antibacterial_and_anti-inflammatory_activities_of_benzimidazole-containing_tricyclic_systems</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jccs.202000454" target="_blank" >10.1002/jccs.202000454</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis, molecular docking, antibacterial, and anti-inflammatory activities of benzimidazole-containing tricyclic systems

Popis výsledku v původním jazyce

In the present study, we reported the synthesis of benzimidazole-containing tricyclic systems and evaluated their antimicrobial efficacy against some Gram-positive, Gram-negative strains, and their anti-inflammatory activity as well as a hemolytic assay in terms of percentage. The antimicrobial study of the synthesized compounds revealed that most of them showed significant activity, and compound 5b displayed excellent antimicrobial efficacy among all. Results showed that the hydroxyl group at the fourth position on the aromatic ring has a substantial role in the biological activity. Synthesized compounds showed promising minimum inhibitory concentration (mu g/mL) values in the range of 1.2-12.8 mu g/mL against the tested strains. The in vitro anti-inflammatory activity of these compounds was evaluated by denaturation of bovine serum albumin method and showed the inhibition in the range of IC50 value 31.16-94.63 mu g/mL. Among all the tested compounds, compound 5b has a significant IC50 value. The percentage of hemolysis of the target compounds ranged from 1.14 to 52.8 at a concentration of 100 mu g/mL. Molecular docking study revealed the good binding interactions against Escherichia coli, and it is best suited with in vitro studies. Pharmacokinetic studies showed the safe profiles for the title compounds.

Název v anglickém jazyce

Synthesis, molecular docking, antibacterial, and anti-inflammatory activities of benzimidazole-containing tricyclic systems

Popis výsledku anglicky

In the present study, we reported the synthesis of benzimidazole-containing tricyclic systems and evaluated their antimicrobial efficacy against some Gram-positive, Gram-negative strains, and their anti-inflammatory activity as well as a hemolytic assay in terms of percentage. The antimicrobial study of the synthesized compounds revealed that most of them showed significant activity, and compound 5b displayed excellent antimicrobial efficacy among all. Results showed that the hydroxyl group at the fourth position on the aromatic ring has a substantial role in the biological activity. Synthesized compounds showed promising minimum inhibitory concentration (mu g/mL) values in the range of 1.2-12.8 mu g/mL against the tested strains. The in vitro anti-inflammatory activity of these compounds was evaluated by denaturation of bovine serum albumin method and showed the inhibition in the range of IC50 value 31.16-94.63 mu g/mL. Among all the tested compounds, compound 5b has a significant IC50 value. The percentage of hemolysis of the target compounds ranged from 1.14 to 52.8 at a concentration of 100 mu g/mL. Molecular docking study revealed the good binding interactions against Escherichia coli, and it is best suited with in vitro studies. Pharmacokinetic studies showed the safe profiles for the title compounds.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Chinese Chemical Society

ISSN

0009-4536

e-ISSN

—

Svazek periodika

68

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

12

Strana od-do

1055-1066

Kód UT WoS článku

000612015400001

EID výsledku v databázi Scopus

2-s2.0-85099796856