Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F22%3A39917771" target="_blank" >RIV/00216275:25310/22:39917771 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/22:73610020

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1388198121002109" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1388198121002109</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbalip.2021.159082" target="_blank" >10.1016/j.bbalip.2021.159082</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues

Popis výsledku v původním jazyce

Lung cancer represents one of the leading worldwide causes of cancer death, but the pathobiochemistry of this disease is still not fully understood. Here we characterize the lipidomic and metabolomic profiles of the tumor and surrounding normal tissues for 23 patients with non-small cell lung cancer. In total, 500 molecular species were identified and quantified by a combination of the lipidomic shotgun tandem mass spectrometry (MS/MS) analysis and the targeted metabolomic approach using liquid chromatography (LC) – MS/MS. The statistical evaluation includes multivariate and univariate methods with the emphasis on paired statistical approaches. Our research revealed significant changes in several biochemical pathways related to the central carbon metabolism, acylcarnitines, dipeptides as well as the disruption in the lipid metabolism observed mainly for glycer- ophospholipids, sphingolipids, and cholesteryl esters.

Název v anglickém jazyce

Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues

Popis výsledku anglicky

Lung cancer represents one of the leading worldwide causes of cancer death, but the pathobiochemistry of this disease is still not fully understood. Here we characterize the lipidomic and metabolomic profiles of the tumor and surrounding normal tissues for 23 patients with non-small cell lung cancer. In total, 500 molecular species were identified and quantified by a combination of the lipidomic shotgun tandem mass spectrometry (MS/MS) analysis and the targeted metabolomic approach using liquid chromatography (LC) – MS/MS. The statistical evaluation includes multivariate and univariate methods with the emphasis on paired statistical approaches. Our research revealed significant changes in several biochemical pathways related to the central carbon metabolism, acylcarnitines, dipeptides as well as the disruption in the lipid metabolism observed mainly for glycer- ophospholipids, sphingolipids, and cholesteryl esters.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/GA18-12204S" target="_blank" >GA18-12204S: Charakterizace lidského lipidomu a metabolomu pro personalizovanou zdravotní péči a hledání biomarkerů: studie rakoviny ledvin</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

ISSN

1388-1981

e-ISSN

1879-2618

Svazek periodika

1867

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

159082

Kód UT WoS článku

000729063500006

EID výsledku v databázi Scopus

2-s2.0-85120402480