Flow injection analysis of ranitidine based on derivatization reaction producing 2-methylfuran cation as a sensitive and selective amperometric detector

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F23%3A39919175" target="_blank" >RIV/00216275:25310/23:39919175 - isvavai.cz</a>

Výsledek na webu

<a href="https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/elan.202200318" target="_blank" >https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/elan.202200318</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elan.202200318" target="_blank" >10.1002/elan.202200318</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Flow injection analysis of ranitidine based on derivatization reaction producing 2-methylfuran cation as a sensitive and selective amperometric detector

Popis výsledku v původním jazyce

A new electrochemical sensor in a flow injection system is developed for the determination of ranitidine in pharmaceutical formulations. The method is based on the deamination reaction of ranitidine in an acidic environment in the presence of nitrite ions producing the electroactive species 2-methylfuran and releasing nitrosamine [1]. A wide linear range of ranitidine from 4.4 to 6000 mg L−1, with correlation coefficient R2 = 0.996 and the detection limit 1.3 mg L−1 was obtained. The method has been applied in tablet analysis and ampoules; the results are within the confidence limits with 95% reliability compared to the reference method with HPLC.

Název v anglickém jazyce

Flow injection analysis of ranitidine based on derivatization reaction producing 2-methylfuran cation as a sensitive and selective amperometric detector

Popis výsledku anglicky

A new electrochemical sensor in a flow injection system is developed for the determination of ranitidine in pharmaceutical formulations. The method is based on the deamination reaction of ranitidine in an acidic environment in the presence of nitrite ions producing the electroactive species 2-methylfuran and releasing nitrosamine [1]. A wide linear range of ranitidine from 4.4 to 6000 mg L−1, with correlation coefficient R2 = 0.996 and the detection limit 1.3 mg L−1 was obtained. The method has been applied in tablet analysis and ampoules; the results are within the confidence limits with 95% reliability compared to the reference method with HPLC.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Electroanalysis

ISSN

1040-0397

e-ISSN

1521-4109

Svazek periodika

35

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

"e202200318"

Kód UT WoS článku

000929356100001

EID výsledku v databázi Scopus

2-s2.0-85147556414