Water-insoluble fibres, threads, and fabrics from lauroyl derivatives of hyaluronan

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F23%3A39920872" target="_blank" >RIV/00216275:25310/23:39920872 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0141813023005470?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0141813023005470?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijbiomac.2023.123654" target="_blank" >10.1016/j.ijbiomac.2023.123654</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Water-insoluble fibres, threads, and fabrics from lauroyl derivatives of hyaluronan

Popis výsledku v původním jazyce

Hyaluronan (HA) is a naturally occurring polysaccharide widely used in medicine and cosmetics. To further broaden its potential, various HA derivatives have been developed with the aim of reducing solubility, slowing degradation, or providing other beneficial properties. However, for most medical applications, these derivatives must be processed into suitable forms. Here we present water-insoluble fibres prepared from lauroyl-modified HA using a wet spinning process. Important properties of the fibres, such as swelling or the degradation rate, can be fine-tuned by adjusting the degree of HA modification. Due to their mechanical properties, the lauroyl HA fibres can be easily processed into threads and subsequently into fabrics of various sizes, shapes, and degrees of porosity. In addition, in vitro cytotoxicity testing of the fibres showed that they were non-cytotoxic. Overall, our results suggest that lauroyl HA fibres are a promising material that could be used to develop a variety of medical devices.

Název v anglickém jazyce

Water-insoluble fibres, threads, and fabrics from lauroyl derivatives of hyaluronan

Popis výsledku anglicky

Hyaluronan (HA) is a naturally occurring polysaccharide widely used in medicine and cosmetics. To further broaden its potential, various HA derivatives have been developed with the aim of reducing solubility, slowing degradation, or providing other beneficial properties. However, for most medical applications, these derivatives must be processed into suitable forms. Here we present water-insoluble fibres prepared from lauroyl-modified HA using a wet spinning process. Important properties of the fibres, such as swelling or the degradation rate, can be fine-tuned by adjusting the degree of HA modification. Due to their mechanical properties, the lauroyl HA fibres can be easily processed into threads and subsequently into fabrics of various sizes, shapes, and degrees of porosity. In addition, in vitro cytotoxicity testing of the fibres showed that they were non-cytotoxic. Overall, our results suggest that lauroyl HA fibres are a promising material that could be used to develop a variety of medical devices.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Biological Macromolecules

ISSN

0141-8130

e-ISSN

1879-0003

Svazek periodika

234

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

123654

Kód UT WoS článku

000946999400001

EID výsledku v databázi Scopus

2-s2.0-85148340457