Recent advances in separation methods for characterization of glutathione metabolism and dietary supplementation
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F24%3A39921478" target="_blank" >RIV/00216275:25310/24:39921478 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S0165993624002346" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0165993624002346</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.trac.2024.117751" target="_blank" >10.1016/j.trac.2024.117751</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Recent advances in separation methods for characterization of glutathione metabolism and dietary supplementation
Popis výsledku v původním jazyce
Glutathione (GSH) is the most important low-molecular intracellular antioxidant. In addition to its antioxidant properties, it ensures many other biological functions, including the elimination of xenobiotics. Glutathione and glutathione disulfide (GSSG) levels can be used as biomarkers of oxidative stress associated with many physiological and pathological conditions at which intracellular GSH levels decrease. Thus enhancing intracellular GSH levels has a wide therapeutic potential. A promising candidate for effective elevation of intracellular GSH levels by simple supplementation is γ-glutamylcysteine. The present review is focused on the description of available methods for characterization of GSH metabolism. Especially, methods utilizing liquid chromatography and liquid chromatography coupled with mass spectrometry for the determination of GSH, GSSG, and otherthiols and related compounds are reviewed and critically discussed.
Název v anglickém jazyce
Recent advances in separation methods for characterization of glutathione metabolism and dietary supplementation
Popis výsledku anglicky
Glutathione (GSH) is the most important low-molecular intracellular antioxidant. In addition to its antioxidant properties, it ensures many other biological functions, including the elimination of xenobiotics. Glutathione and glutathione disulfide (GSSG) levels can be used as biomarkers of oxidative stress associated with many physiological and pathological conditions at which intracellular GSH levels decrease. Thus enhancing intracellular GSH levels has a wide therapeutic potential. A promising candidate for effective elevation of intracellular GSH levels by simple supplementation is γ-glutamylcysteine. The present review is focused on the description of available methods for characterization of GSH metabolism. Especially, methods utilizing liquid chromatography and liquid chromatography coupled with mass spectrometry for the determination of GSH, GSSG, and otherthiols and related compounds are reviewed and critically discussed.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10406 - Analytical chemistry
Návaznosti výsledku
Projekt
<a href="/cs/project/GA22-09556S" target="_blank" >GA22-09556S: Samoadaptivní vícerozměrné separace v kapalné fázi</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
TrAC - Trends in Analytical Chemistry
ISSN
0165-9936
e-ISSN
1879-3142
Svazek periodika
176
Číslo periodika v rámci svazku
July 2024
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
14
Strana od-do
117751
Kód UT WoS článku
001294703200001
EID výsledku v databázi Scopus
2-s2.0-85192951171