Baclofen and Clonazepam Overdose in a Patient with Chronic Neck and Shoulder Pain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25520%2F17%3A39910904" target="_blank" >RIV/00216275:25520/17:39910904 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/17:43916011 RIV/00064173:_____/17:N0000167

Výsledek na webu

<a href="http://dx.doi.org/10.14735/amcsnn2017714" target="_blank" >http://dx.doi.org/10.14735/amcsnn2017714</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn2017714" target="_blank" >10.14735/amcsnn2017714</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Baclofen and Clonazepam Overdose in a Patient with Chronic Neck and Shoulder Pain

Popis výsledku v původním jazyce

Baclofen, a derivative of gama-aminobutyric acid, is used for symptomatic relief of skeletal muscle spasms and spasticity, particularly in patients with multiple sclerosis. Most published cases of baclofen overdose include acute intentional overdose or intoxication in the context of spasmolytic treatment. The effects of baclofen overdosage may cover a broad variety of clinical manifestations including coma, muscle flaccidity, seizures, severe respirátory depression with need for mechanical ventilation, autonomic disturbances with abnormal heart rate (either bradycardia or tachycardia), hypo- or hypertension, and either miosis or mydriasis. We report a 42-year-old man who was found with generalized convulsive seizures and referred in state of deep coma. Toxicological analysis of blood and urine disclosed clonazepam and a high level of baclofen. Only with oxygen inhalation and supportive diuretic therapy he regain consioussness after 28 hours.

Název v anglickém jazyce

Baclofen and Clonazepam Overdose in a Patient with Chronic Neck and Shoulder Pain

Popis výsledku anglicky

Baclofen, a derivative of gama-aminobutyric acid, is used for symptomatic relief of skeletal muscle spasms and spasticity, particularly in patients with multiple sclerosis. Most published cases of baclofen overdose include acute intentional overdose or intoxication in the context of spasmolytic treatment. The effects of baclofen overdosage may cover a broad variety of clinical manifestations including coma, muscle flaccidity, seizures, severe respirátory depression with need for mechanical ventilation, autonomic disturbances with abnormal heart rate (either bradycardia or tachycardia), hypo- or hypertension, and either miosis or mydriasis. We report a 42-year-old man who was found with generalized convulsive seizures and referred in state of deep coma. Toxicological analysis of blood and urine disclosed clonazepam and a high level of baclofen. Only with oxygen inhalation and supportive diuretic therapy he regain consioussness after 28 hours.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

—

Svazek periodika

80/113

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

3

Strana od-do

714-716

Kód UT WoS článku

000417541400014

EID výsledku v databázi Scopus

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