Psychotomimetic Agent BZ (3-quinuclidinyl benzilate)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25520%2F20%3A39917090" target="_blank" >RIV/00216275:25520/20:39917090 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.elsevier.com/books/handbook-of-toxicology-of-chemical-warfare-agents/gupta/978-0-12-819090-6" target="_blank" >https://www.elsevier.com/books/handbook-of-toxicology-of-chemical-warfare-agents/gupta/978-0-12-819090-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-819090-6.00014-3" target="_blank" >10.1016/B978-0-12-819090-6.00014-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Psychotomimetic Agent BZ (3-quinuclidinyl benzilate)

Popis výsledku v původním jazyce

BZ agent is the code for 3-quinuclidinyl benzilate, a psychotomimetic chemical warfare agent belonging to the family of anticholinergic hallucinogens. BZ is a competitive inhibitor of acetylcholine acting at the postsynaptic muscarinic receptors. Low doses of BZ are able to induce severe and long term anticholinergic psychotomimetics effect. The effect is characterized as vegetative symptoms progressing into confusion, hallucinations and other psychotic symptoms. The mechanism of action is based on BZ interaction with cholinergic receptors in the central and peripheral nervous system, resulting to lack of neuromediator acetylcholine. Antidotal effect against BZ intoxication is based on an increase of acetylcholine levels using reversible cholinesterase inhibitors. Physostigmine was historically used as an antidote against BZ. However, physostigmine has been omitted due to high toxicity and severe side effects and replaced by advanced cholinesterase inhibitors, including e.g. acridine derivatives. From these compounds, 7-methoxytacrine was the one of widely investigated potential antidotes.

Název v anglickém jazyce

Psychotomimetic Agent BZ (3-quinuclidinyl benzilate)

Popis výsledku anglicky

BZ agent is the code for 3-quinuclidinyl benzilate, a psychotomimetic chemical warfare agent belonging to the family of anticholinergic hallucinogens. BZ is a competitive inhibitor of acetylcholine acting at the postsynaptic muscarinic receptors. Low doses of BZ are able to induce severe and long term anticholinergic psychotomimetics effect. The effect is characterized as vegetative symptoms progressing into confusion, hallucinations and other psychotic symptoms. The mechanism of action is based on BZ interaction with cholinergic receptors in the central and peripheral nervous system, resulting to lack of neuromediator acetylcholine. Antidotal effect against BZ intoxication is based on an increase of acetylcholine levels using reversible cholinesterase inhibitors. Physostigmine was historically used as an antidote against BZ. However, physostigmine has been omitted due to high toxicity and severe side effects and replaced by advanced cholinesterase inhibitors, including e.g. acridine derivatives. From these compounds, 7-methoxytacrine was the one of widely investigated potential antidotes.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Handbook of Toxicology of Chemical Warfare Agents

ISBN

978-0-12-819090-6

Počet stran výsledku

11

Strana od-do

203-213

Počet stran knihy

1318

Název nakladatele

Academic Press (Elsevier)

Místo vydání

Cambridge

Kód UT WoS kapitoly

—