Mechanical properties of vascular smooth muscle cells

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Mechanical properties of vascular smooth muscle cells

Popis výsledku v původním jazyce

Mechanical properties of vascular smooth muscle cells are closely related to their physiological function within the arterial wall (blood pressure regulation, arterial remodelling, healing and growth. Mechanical stimuli represent a very important factorinfluencing cellular processes and functions. The knowledge about mechanical properties of cells is necessary for understanding how cells response to mechanical stress and strain. A lot of experiments are carried out with the aim to determine mechanicalproperties of cells (tensile test, compression test, micropipette aspiration test, indentation test). A 3D finite element model of adherent cell for computational simulation of indentation test is presented in this paper. Our model considers all significant structural cellular components, i.e. actin cortex, deep cytoskeleton, cytoplasma and nucleus. The geometry model is based on experimental observations of a spreading fibroblast. Actin cortex was modelled as a thin membrane meshed with

Název v anglickém jazyce

Mechanical properties of vascular smooth muscle cells

Popis výsledku anglicky

Mechanical properties of vascular smooth muscle cells are closely related to their physiological function within the arterial wall (blood pressure regulation, arterial remodelling, healing and growth. Mechanical stimuli represent a very important factorinfluencing cellular processes and functions. The knowledge about mechanical properties of cells is necessary for understanding how cells response to mechanical stress and strain. A lot of experiments are carried out with the aim to determine mechanicalproperties of cells (tensile test, compression test, micropipette aspiration test, indentation test). A 3D finite element model of adherent cell for computational simulation of indentation test is presented in this paper. Our model considers all significant structural cellular components, i.e. actin cortex, deep cytoskeleton, cytoplasma and nucleus. The geometry model is based on experimental observations of a spreading fibroblast. Actin cortex was modelled as a thin membrane meshed with

Druh

D - Stať ve sborníku

CEP obor

JR - Ostatní strojírenství

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 7th International Scientific Conference Applied Mechanics 2005

ISBN

80-214-2373-0

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

65-65

Název nakladatele

VUT Brno

Místo vydání

Hrotovice

Místo konání akce

Hrotovice

Datum konání akce

29. 3. 2005

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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