EXPERIMENTAL STUDY OF AEROSOL DEPOSITION IN A REALISTIC MODEL OF THE LUNG

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

EXPERIMENTAL STUDY OF AEROSOL DEPOSITION IN A REALISTIC MODEL OF THE LUNG

Popis výsledku v původním jazyce

The inhalation route for administration of medicaments is becoming more and more popular in recent years. The reason is non-invasiveness of the method and instantaneous absorption of drugs to the blood circulation. It is necessary to deliver exact amountof drug to the specific segment because of occurrence of diverse diseases in different segments of lungs. The aim of our work is to contribute to better understanding of transport and deposition of aerosolized drugs in lungs and hence to more effectivetreatment of respiratory diseases due to the targeted drug delivery. We provided measurements of aerosol deposition in segmented realistic model of lungs without a mouth cavity. Monodisperse particles marked with fluorescein were supplied to the model. The model was then disassembled to segments and each segment was rinsed with isopropanol, whereby fluorescent samples were created. Each sample was analysed by fluorometer and an amount of aerosol deposited in the segment was calculated. E

Název v anglickém jazyce

EXPERIMENTAL STUDY OF AEROSOL DEPOSITION IN A REALISTIC MODEL OF THE LUNG

Popis výsledku anglicky

The inhalation route for administration of medicaments is becoming more and more popular in recent years. The reason is non-invasiveness of the method and instantaneous absorption of drugs to the blood circulation. It is necessary to deliver exact amountof drug to the specific segment because of occurrence of diverse diseases in different segments of lungs. The aim of our work is to contribute to better understanding of transport and deposition of aerosolized drugs in lungs and hence to more effectivetreatment of respiratory diseases due to the targeted drug delivery. We provided measurements of aerosol deposition in segmented realistic model of lungs without a mouth cavity. Monodisperse particles marked with fluorescein were supplied to the model. The model was then disassembled to segments and each segment was rinsed with isopropanol, whereby fluorescent samples were created. Each sample was analysed by fluorometer and an amount of aerosol deposited in the segment was calculated. E

Druh

D - Stať ve sborníku

CEP obor

BK - Mechanika tekutin

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

XXIX. mezinárodní konference Setkání kateder mechaniky tekutin a termomechaniky

ISBN

978-80-248-2244-0

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

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Název nakladatele

VŠB - TU Ostrava

Místo vydání

Rožnov pod Radhoštěm

Místo konání akce

Rožnov pod Radhoštěm

Datum konání akce

23. 6. 2010

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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