Comparison of methods for evaluation of aerosol deposition in the model of human lungs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F14%3APU106786" target="_blank" >RIV/00216305:26210/14:PU106786 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1051/epjconf/20146702006" target="_blank" >http://dx.doi.org/10.1051/epjconf/20146702006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1051/epjconf/20146702006" target="_blank" >10.1051/epjconf/20146702006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of methods for evaluation of aerosol deposition in the model of human lungs

Popis výsledku v původním jazyce

It seems to be very convenient to receive a medicine by inhalation instead of injection. Unfortunately transport of particles and targeted delivery of a drug in human respiratory airways is very complicated task. Therefore we carried out experiments and tested different methods for evaluation of particle deposition in a model of human lungs. The model included respiratory airways from oral cavity to 7th generation of branching. Particles were dispersed by TSI Small-scale Powder Disperser 3433 and delivered to the model. The model was disassembled into segments after the deposition of the particles and local deposition was measured. Two methods were used to analyse the samples, fluorescence spectroscopy and optical microscopy. The first method was based on measuring the intensity of luminescence, which represented the particle deposition. The second method used the optical microscope with phase-contrast objective. A dispersion of isopropanol and particles was filtrated using a vacuum filtration unit, a filter was placed on glass slide and made transparent. The particles on the filter were counted manually and the deposition was calculated afterwards. The results of the methods were compared and both methods proved to be useful.

Název v anglickém jazyce

Comparison of methods for evaluation of aerosol deposition in the model of human lungs

Popis výsledku anglicky

It seems to be very convenient to receive a medicine by inhalation instead of injection. Unfortunately transport of particles and targeted delivery of a drug in human respiratory airways is very complicated task. Therefore we carried out experiments and tested different methods for evaluation of particle deposition in a model of human lungs. The model included respiratory airways from oral cavity to 7th generation of branching. Particles were dispersed by TSI Small-scale Powder Disperser 3433 and delivered to the model. The model was disassembled into segments after the deposition of the particles and local deposition was measured. Two methods were used to analyse the samples, fluorescence spectroscopy and optical microscopy. The first method was based on measuring the intensity of luminescence, which represented the particle deposition. The second method used the optical microscope with phase-contrast objective. A dispersion of isopropanol and particles was filtrated using a vacuum filtration unit, a filter was placed on glass slide and made transparent. The particles on the filter were counted manually and the deposition was calculated afterwards. The results of the methods were compared and both methods proved to be useful.

Druh

D - Stať ve sborníku

CEP obor

JR - Ostatní strojírenství

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

EPJ Web of Conferences

ISBN

978-80-260-5375-0

ISSN

2100-014X

e-ISSN

—

Počet stran výsledku

4

Strana od-do

82-85

Název nakladatele

E D P SCIENCES

Místo vydání

FRANCE

Místo konání akce

Kutná Hora

Datum konání akce

19. 11. 2013

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000343672100009