Computational model of vascular smooth muscle cell.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F15%3APU115243" target="_blank" >RIV/00216305:26210/15:PU115243 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Computational model of vascular smooth muscle cell.

Popis výsledku v původním jazyce

The cytoskeleton plays a vital role in defining the mechanical behavior of cell subjected to external mechanical stimuli. The cellular tensegrity model views the cytoskeleton as a reticulated mechanical structure, where the tensile prestress generated byactomyosin filaments is balanced internally via compression-supporting stuctures such as microtubules and externally via extracellular matrix. The 3D finite element model of vascular smooth muscle cell (VSMC) presented here is based on hybrid modellingapproach, where the cytoplasm and the nucleus (violet) are modelled using continuum approach and the cytoskeleton is modelled using microstructural approach. The structural arrangement and elastic properties of the constituents of the cytoskeletal network are based on the experimental observations and measurements respectively and are obtained from the literature. The non-contractile actin cortex underneath the plasma membrane is modelled using shell elements, the actin bundles (light bl

Název v anglickém jazyce

Computational model of vascular smooth muscle cell.

Popis výsledku anglicky

The cytoskeleton plays a vital role in defining the mechanical behavior of cell subjected to external mechanical stimuli. The cellular tensegrity model views the cytoskeleton as a reticulated mechanical structure, where the tensile prestress generated byactomyosin filaments is balanced internally via compression-supporting stuctures such as microtubules and externally via extracellular matrix. The 3D finite element model of vascular smooth muscle cell (VSMC) presented here is based on hybrid modellingapproach, where the cytoplasm and the nucleus (violet) are modelled using continuum approach and the cytoskeleton is modelled using microstructural approach. The structural arrangement and elastic properties of the constituents of the cytoskeletal network are based on the experimental observations and measurements respectively and are obtained from the literature. The non-contractile actin cortex underneath the plasma membrane is modelled using shell elements, the actin bundles (light bl

Druh

O - Ostatní výsledky

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

<a href="/cs/project/LO1202" target="_blank" >LO1202: NETME CENTRE PLUS</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů