Effect of Hyaluronic Acid on Friction of Articular Cartilage

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F18%3APU128557" target="_blank" >RIV/00216305:26210/18:PU128557 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.engmech.cz/improc/2018/709.pdf" target="_blank" >http://www.engmech.cz/improc/2018/709.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21495/91-8-709" target="_blank" >10.21495/91-8-709</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of Hyaluronic Acid on Friction of Articular Cartilage

Popis výsledku v původním jazyce

Intra-articular injections of hyaluronic acid based solutions are gaining popularity as a treatment option for non-operative management of patients with degenerative joint diseases. Although there is a plenty of evidence for lowering of friction in large human joints by exogenous hyaluronic acid, the physical phenomenon standing behind these results has not been clarified yet. This leads to large dispersion in effectiveness and duration in action of viscosupplementation as a treatment for osteoarthritis and; subsequently, to disparity between the view of practitioners and recent procedures questioning or disregarding the efficiency of hyaluronic acid injections. In this study, the changes in friction between intact porcine cartilage and glass plate during reciprocating sliding tests were observed to better understand interaction between hyaluronic acid and synovial fluid components. Contact was lubricated with protein solutions both with and without addition of hyaluronic acid. The effectiveness of proteins and influence of hyaluronic acid on friction are discussed.

Název v anglickém jazyce

Effect of Hyaluronic Acid on Friction of Articular Cartilage

Popis výsledku anglicky

Intra-articular injections of hyaluronic acid based solutions are gaining popularity as a treatment option for non-operative management of patients with degenerative joint diseases. Although there is a plenty of evidence for lowering of friction in large human joints by exogenous hyaluronic acid, the physical phenomenon standing behind these results has not been clarified yet. This leads to large dispersion in effectiveness and duration in action of viscosupplementation as a treatment for osteoarthritis and; subsequently, to disparity between the view of practitioners and recent procedures questioning or disregarding the efficiency of hyaluronic acid injections. In this study, the changes in friction between intact porcine cartilage and glass plate during reciprocating sliding tests were observed to better understand interaction between hyaluronic acid and synovial fluid components. Contact was lubricated with protein solutions both with and without addition of hyaluronic acid. The effectiveness of proteins and influence of hyaluronic acid on friction are discussed.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20301 - Mechanical engineering

Projekt

<a href="/cs/project/LTAUSA17150" target="_blank" >LTAUSA17150: Vliv tribologických procesů na životnost náhrad kolenního kloubu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Engineering Mechanics 2018

ISBN

978-80-86246-91-8

ISSN

—

e-ISSN

—

Počet stran výsledku

4

Strana od-do

709-712

Název nakladatele

Institute of Theretical and Applied Mechanics of the Czech Academy of Sciences

Místo vydání

Praha

Místo konání akce

Svratka

Datum konání akce

14. 5. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000465489800177