Bendo-tensegrity model simulates compression test of animal cell

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F18%3APU130037" target="_blank" >RIV/00216305:26210/18:PU130037 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.engmech.cz/improc/2018/45.pdf" target="_blank" >http://www.engmech.cz/improc/2018/45.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21495/91-8-45" target="_blank" >10.21495/91-8-45</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bendo-tensegrity model simulates compression test of animal cell

Popis výsledku v původním jazyce

A hybrid model of suspended animal cell proposed earlier, with a bendo-tensegrity structure mimicking cytoskeleton, is applied to simulate the global response of the cell under compression and to describe mechanical behaviour of its components. The Finite Element model incorporates Microtubules, Actin Filaments, Intermediate Filaments, nucleus, cytoplasm, and Cell Membrane, all of them with realistic geometrical and material parameters. The unique features of this structural model keep fundamental principles governing cell behaviour, such as interaction between the cytoskeletal components redistributing the prestress of actin filaments throughout all the structure. The force-deformation curve from the simulated compression test with microplates is validated by comparison with the experimental response from literature. The model enables us to investigate the mechanical role of individual celular and cytoskeletal components in intracellular force propagation by means of changing their numbers or parameters. As quantitative characterization of nucleus deformation may be hypothetically decisive for mechanotransduction, the model aims at better understanding of how cellular processes are mechanically controlled.

Název v anglickém jazyce

Bendo-tensegrity model simulates compression test of animal cell

Popis výsledku anglicky

A hybrid model of suspended animal cell proposed earlier, with a bendo-tensegrity structure mimicking cytoskeleton, is applied to simulate the global response of the cell under compression and to describe mechanical behaviour of its components. The Finite Element model incorporates Microtubules, Actin Filaments, Intermediate Filaments, nucleus, cytoplasm, and Cell Membrane, all of them with realistic geometrical and material parameters. The unique features of this structural model keep fundamental principles governing cell behaviour, such as interaction between the cytoskeletal components redistributing the prestress of actin filaments throughout all the structure. The force-deformation curve from the simulated compression test with microplates is validated by comparison with the experimental response from literature. The model enables us to investigate the mechanical role of individual celular and cytoskeletal components in intracellular force propagation by means of changing their numbers or parameters. As quantitative characterization of nucleus deformation may be hypothetically decisive for mechanotransduction, the model aims at better understanding of how cellular processes are mechanically controlled.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Engineering Mechanics 2018

ISBN

978-80-86246-88-8

ISSN

—

e-ISSN

—

Počet stran výsledku

4

Strana od-do

45-48

Název nakladatele

Neuveden

Místo vydání

Neuveden

Místo konání akce

Svratka

Datum konání akce

14. 5. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000465489800011