Numerical simulation of fibre deposition in oral and large bronchial airways in comparison with experiments

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F19%3APU132483" target="_blank" >RIV/00216305:26210/19:PU132483 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0021850218304373?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0021850218304373?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jaerosci.2019.06.003" target="_blank" >10.1016/j.jaerosci.2019.06.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Numerical simulation of fibre deposition in oral and large bronchial airways in comparison with experiments

Popis výsledku v původním jazyce

Inhaled asbestos fibres have been implicated in causal relationships with increased frequencies of non-malignant pleural disease, asbestosis, mesothelioma and lung cancer. Replacement fibres are considered to be less harmful, however, their health effects are not fully understood. The objective of the present work was to implement and apply numerical fibre tracking techniques in order to simulate the deposition of fibres in a complex oro-pharyngeal-laryngeal-bronchial system at different inhalation flow rates and compare the results with the outcomes of recent measurements performed in the same geometry. Two different approaches for the estimation of drag force were considered. Simulated deposition efficiency values agreed reasonably well with the experimentally determined values, however, the drag model which considers the anisotropic nature of the geometry of fibres performed better than the one which accounted only for the their non-spherical shape. The highest values of deposition density correlated well with the location of primary lesions observed in pathological studies.

Název v anglickém jazyce

Numerical simulation of fibre deposition in oral and large bronchial airways in comparison with experiments

Popis výsledku anglicky

Inhaled asbestos fibres have been implicated in causal relationships with increased frequencies of non-malignant pleural disease, asbestosis, mesothelioma and lung cancer. Replacement fibres are considered to be less harmful, however, their health effects are not fully understood. The objective of the present work was to implement and apply numerical fibre tracking techniques in order to simulate the deposition of fibres in a complex oro-pharyngeal-laryngeal-bronchial system at different inhalation flow rates and compare the results with the outcomes of recent measurements performed in the same geometry. Two different approaches for the estimation of drag force were considered. Simulated deposition efficiency values agreed reasonably well with the experimentally determined values, however, the drag model which considers the anisotropic nature of the geometry of fibres performed better than the one which accounted only for the their non-spherical shape. The highest values of deposition density correlated well with the location of primary lesions observed in pathological studies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20301 - Mechanical engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF AEROSOL SCIENCE

ISSN

0021-8502

e-ISSN

1879-1964

Svazek periodika

136

Číslo periodika v rámci svazku

2019-10-31

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

000487931100001

EID výsledku v databázi Scopus

2-s2.0-85067406074